7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-

Base Information

Chemical Name:7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-
CAS No.:243665-87-4
Molecular Formula:C18H13FN4
Molecular Weight:304.326
Hs Code.:
DSSTox Substance ID:DTXSID60442240
Nikkaji Number:J1.176.982I
Wikidata:Q82259413
Mol file:243665-87-4.mol

Synonyms:243665-87-4;7-(4-Fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-;DTXSID60442240;5-Phenyl-7-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine

Suppliers and Price of 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:304.11242459
Heavy Atom Count:23
Complexity:393

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CN(C3=NC=NC(=C23)N)C4=CC=C(C=C4)F

Technology Process of 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl-

There total 4 articles about 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(4-fluorophenyl)-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 507273-48-5
7-(4-fluorophenyl)-9-phenyltetrazolo[1,5-c]-7H-pyrrolo[3,2-e]pyrimidine

: 243665-87-4
4-amino-7-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With potassium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; In acetonitrile; at 80 ℃;
DOI:10.1055/s-2006-950206

Reference yield: 48.0%

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 243665-80-7
2-amino-1-(4-fluoro-phenyl)-4-phenyl-1H-pyrrole-3-carbonitrile

: 243665-87-4
4-amino-7-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With formic acid; In N,N-dimethyl-formamide; Heating;
DOI:10.1002/jhet.5570360325

Reference yield:

: 4651-78-9
2-bromo-1-phenylethylidenemalononitrile

: 243665-87-4
4-amino-7-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / propan-2-ol / 1 h / 60 - 65 °C

2: 48 percent / HCOOH / dimethylformamide / Heating

With formic acid; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jhet.5570360325