2-(3-Bromopropyl)-2-methyl-1,3-dioxolane

Base Information

• Chemical Name: 2-(3-Bromopropyl)-2-methyl-1,3-dioxolane
• CAS No.: 24400-75-7
• Molecular Formula: C7H13BrO2
• Molecular Weight: 209.083
• Hs Code.: 2932999099
• European Community (EC) Number: 440-490-7
• DSSTox Substance ID: DTXSID60339924
• Nikkaji Number: J122.261I
• Wikidata: Q82109250
• Mol file: 24400-75-7.mol

Synonyms:2-(3-Bromopropyl)-2-methyl-1,3-dioxolane;24400-75-7;1,3-Dioxolane, 2-(3-bromopropyl)-2-methyl-;5-Bromo-2,2-ethylenedioxypentane;2-Methyl-2-(3-bromopropyl)-1,3-dioxolane;1-Bromo-4-pentanone ethylene ketal;SCHEMBL253950;DTXSID60339924;5-bromo-2,2-ethylenedioxy-pentane;5-bromo-2-pentanone ethylene ketal;5-Bromopentan-2-one ethylene ketal;MFCD16295474;AKOS016356086;NS-02312;CS-0336247;FT-0708298;2-(3-Bromopropyl)-2-methyl-1,3-dioxolane #;3-(2-methyl-1,3-dioxolan-2-yl)propyl bromide

Chemical Property of 2-(3-Bromopropyl)-2-methyl-1,3-dioxolane

Chemical Property:

• PSA: 18.46000
• LogP: 1.92450
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 208.00989
• Heavy Atom Count: 10
• Complexity: 99.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCCO1)CCCBr

Technology Process of 2-(3-Bromopropyl)-2-methyl-1,3-dioxolane

There total 1 articles about 2-(3-Bromopropyl)-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol (29021-98-5) → ethylene-cetal de la bromo-5 pentanone-2 (24400-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating

2: 96 percent / p-TsOH / benzene / 5 h / Heating

With chloro-trimethyl-silane; toluene-4-sulfonic acid; lithium bromide; In acetonitrile; benzene;

DOI:10.1002/jlcr.2580360806

Reference yield: 94.0%

ethylene-cetal de la bromo-5 pentanone-2 (24400-75-7) + 3-methylcyclohexen-2-one (1193-18-6) → 3-methyl-2-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-cyclohex-2-enone (586977-97-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(03)00286-2

Reference yield: 91.0%

ethylene-cetal de la bromo-5 pentanone-2 (24400-75-7) + triphenylphosphine (603-35-0) → (5-Brom-pentanon-(2)-aethylenacetal)-phosphoniumbromid (5944-33-2)

Guidance literature:

at 130 ℃; for 1h;

DOI:10.1021/ja00372a020

upstream raw materials:

3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol

Downstream raw materials:

hept-6-yn-2-one

(+)-17β-Benzoyloxy-4.5-seco-oestren-(9)-dion-(3.5)

2-(4-benzyloxy-pyrimidin-2-yl)-5-(2-methyl-[1,3]dioxolan-2-yl)-pentanoic acid ethyl ester

8-methyl-9-phenylthionon-7-en-2-one ethylene ketal

Refernces

• 1、 -. "METHODS FOR TREATING NEURON DAMAGE". Paragraph 0304. . Retrieved 2014/07/22.
• 2、 -. "GGA AND GGA DERIVATIVES, COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM". Paragraph 0277; 0280. . Retrieved 2013/09/12.