(7aS,13aS)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one

Base Information

• Chemical Name: (7aS,13aS)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
• CAS No.: 110549-03-6
• Molecular Formula: C₂₃H₂₂O₇
• Molecular Weight: 410.423
• Mol file: 110549-03-6.mol

Synonyms:3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one,13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)- (9CI)

Chemical Property of (7aS,13aS)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one

Chemical Property:

• Vapor Pressure: 2.11E-16mmHg at 25°C
• Boiling Point: 623.4°C at 760 mmHg
• Flash Point: 219.3°C
• Density: 1.341g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (7aS,13aS)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one

There total 36 articles about (7aS,13aS)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cis-deguelin (522-17-8,54324-46-8,110508-99-1,123000-18-0) → (+/-)-tephrosin (76-80-2,561-35-3,16277-84-2,110549-03-6)

Guidance literature:

With copper(I) oxide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; In dimethyl sulfoxide; at 20 ℃; for 5h;

DOI:10.1021/acs.jnatprod.7b00794

Reference yield: 53.0%

(-)-deguelin (522-17-8,54324-46-8,110508-99-1,123000-18-0) → (±)-12a-epi-tephrosin (76-80-2,561-35-3,16277-84-2,110549-03-6) + (+/-)-tephrosin (76-80-2,561-35-3,16277-84-2,110549-03-6)

Guidance literature:

With copper(I) oxide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; In dimethyl sulfoxide; at 20 ℃; for 4.5h;

DOI:10.1055/s-0037-1611654

Reference yield: 53.0%

(-)-deguelin (522-17-8,54324-46-8,110508-99-1,123000-18-0) → (±)-12a-epi-tephrosin (76-80-2,561-35-3,16277-84-2,110549-03-6) + (+/-)-tephrosin (76-80-2,561-35-3,16277-84-2,110549-03-6)

Guidance literature:

With copper(I) oxide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; In dimethyl sulfoxide; at 20 ℃; for 4.5h;

DOI:10.1055/s-0037-1611654

upstream raw materials:

3-fluorophenol

2-(3-fluorophenoxy)tetrahydro-2H-pyran