2-Hydroxy-3-methylbutanoic acid ethyl ester

Base Information

• Chemical Name: 2-Hydroxy-3-methylbutanoic acid ethyl ester
• CAS No.: 2441-06-7
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Hs Code.: 2918199090
• Mol file: 2441-06-7.mol

Synonyms:Butanoic acid,2-hydroxy-3-methyl-,ethyl ester;ethyl 3-methyl-2-oxidanyl-butanoate;Butyric acid,2-hydroxy-3-methyl-,ethyl ester;

Chemical Property of 2-Hydroxy-3-methylbutanoic acid ethyl ester

Chemical Property:

• Boiling Point: 112-114 °C(Press: 110 Torr)
• PKA: 13.07±0.20(Predicted)
• PSA: 46.53000
• Density: 1.002±0.06 g/cm3(Predicted)
• LogP: 0.56640

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-3-methylbutanoic acid ethyl ester

There total 1 articles about 2-Hydroxy-3-methylbutanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethyl 3-methyl-2-oxobutanoate (20201-24-5) → 3-methylbutane-1,2-diol (50468-22-9) + ethyl 2-hydroxy-3-methylbutanoate (2441-06-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2010.04.062

Reference yield: 88.0%

Benzyloxymethyl chloride (3587-60-8) + ethyl 2-hydroxy-3-methylbutanoate (2441-06-7) → 2-Benzyloxymethoxy-3-methyl-butyric acid ethyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine;

Reference yield: 67.0%

4-chloro-2-fluoro-5-isopropyloxyphenyl isocyanate (85113-29-7) + ethyl 2-hydroxy-3-methylbutanoate (2441-06-7) → ethyl 2-{N-(2'-fluoro-4'-chloro-5'-isopropoxyphenyl)carbamoyloxy}isovalerate

Guidance literature:

With triethylamine; methyloxirane;

upstream raw materials:

ethyl 3-methyl-2-oxobutanoate

Downstream raw materials:

2,4-dimethyl-pentane-2,3-diol

3-methylbutane-1,2-diol

N-phenyl-2-hydroxy-3-methyl-butanamide

α-phenylcarbamoyloxy-isovaleric acid