2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

Base Information

• Chemical Name: 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V
• CAS No.: 24418-86-8
• Molecular Formula: C15H10O4
• Molecular Weight: 254.242
• Mol file: 24418-86-8.mol

Synonyms:2-[1-(3,4-Dihydroxy-phenyl)-meth-(Z)-ylidene]-benzofuran-3-one;(Z)-2-(3,4-dihydroxybenzylidene)benzofuran-3(2H)-one;Z-2-[(3,4-dihydroxyphenyl)methylene]benzo[b]furan-3-one;2-(3,4-dihydroxy-benzylidene)-benzofuran-3-one;2-((Z)-3,4-dihydroxy-benzylidene)-benzofuran-3-one;2-((Z)-3,4-Dihydroxy-benzyliden)-benzofuran-3-on;2-(3,4-Dihydroxy-benzyliden)-benzofuran-3-on;

Chemical Property of 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

Chemical Property:

• Melting Point: 223 - 225 °C
• Boiling Point: 493.2±45.0 °C(Predicted)
• PKA: 8.99±0.10(Predicted)
• PSA: 66.76000
• Density: 1.489±0.06 g/cm3(Predicted)
• LogP: 2.71400
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

SKIV ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

There total 11 articles about 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(Z)-2-(3,4-dimethoxybenzylidene)benzofuran-3(2H)-one (63831-46-9) → (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]benzofuran-3-one (24418-86-8)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2014.10.019

Reference yield: 60.0%

3-oxo-2,3-dihydrobenzo[b]furan (7169-34-8) + 3,4-dihydroxybenzaldehyde (139-85-5) → (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]benzofuran-3-one (24418-86-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.2174/1570180815666180712150600

Reference yield: 40.0%

3,4,2'-trihydroxy-trans-chalcone (88191-21-3) → (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]benzofuran-3-one (24418-86-8)

Guidance literature:

With pyridine; mercury(II) diacetate; for 1h; Heating;

DOI:10.1016/j.tet.2007.04.048

upstream raw materials:

3-oxo-2,3-dihydrobenzo[b]furan

3,4-dihydroxybenzaldehyde

3,4,2'-trihydroxy-trans-chalcone

o-hydroxyacetophenone

Refernces

• 1、 Roshanzamir, Khashayar,Kashani-Amin, Elaheh,Ebrahim-Habibi, Azadeh,Navidpour, Latifeh. "Aurones as new porcine pancreatic α-amylase inhibitors". . p. 333 - 340. Retrieved 2019/06/20.
• 2、 Zwick, Vincent,Chatzivasileiou, Alkiviadis-Orfefs,Deschamps, Nathalie,Roussaki, Marina,Simes-Pires, Claudia A.,Nurisso, Alessandra,Denis, Iza,Blanquart, Christophe,Martinet, Nadine,Carrupt, Pierre-Alain,Detsi, Anastasia,Cuendet, Muriel. "Aurones as histone deacetylase inhibitors: Identification of key features". . p. 5497 - 5501. Retrieved 2014/12/12.