1(2H)-Pyrimidinecarboxylic acid, 3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)-

Base Information

Chemical Name:1(2H)-Pyrimidinecarboxylic acid, 3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)-
CAS No.:245351-09-1
Molecular Formula:C34H37N3O6
Molecular Weight:583.684
Hs Code.:

1(2H)-Pyrimidinecarboxylic acid,
3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen
ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)-

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Chemical Property of 1(2H)-Pyrimidinecarboxylic acid, 3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)-

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Technology Process of 1(2H)-Pyrimidinecarboxylic acid, 3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)-

There total 5 articles about 1(2H)-Pyrimidinecarboxylic acid, 3-[(2S,3S)-3-[(benzoyloxy)(phenylmethyl)amino]-2-methyl-1-oxo-3-phen ylpropyl]-2-(1,1-dimethylethyl)-3,4-dihydro-4-oxo-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 134772-94-4
(S)-2-tert-butyl-1-carbomethoxy-3-propionyl-2,3-dihydro-4(1H)-pyrimidinone

: N-benzoyloxy-N-benzylidenebenzylammonium chloride

: 245351-09-1
(2S)-3-[(2S,3S)-3-(N-benzoyloxy-N-benzylamino)-2-methyl-3-phenylpropionyl]-2-t-butyl-2,3-dihydro-1-methoxycarbonyl-4(1H)pyrimidinone

Guidance literature:: (S)-2-tert-butyl-1-carbomethoxy-3-propionyl-2,3-dihydro-4(1H)-pyrimidinone; With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

N-benzoyloxy-N-benzylidenebenzylammonium chloride; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1246/bcsj.73.2423

Reference yield: 79.0%

: N-benzoyloxy-N-benzylidenebenzylammonium chloride

: C₁₃H₁₉N₂O₄^(1-)*C₃H₇O^(1-)*2Cl^(1-)*Ti⁽⁴⁺⁾

: 245351-09-1
(2S)-3-[(2S,3S)-3-(N-benzoyloxy-N-benzylamino)-2-methyl-3-phenylpropionyl]-2-t-butyl-2,3-dihydro-1-methoxycarbonyl-4(1H)pyrimidinone

Guidance literature:: In dichloromethane;
DOI:10.1246/cl.1999.795

Reference yield:

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: 245351-09-1
(2S)-3-[(2S,3S)-3-(N-benzoyloxy-N-benzylamino)-2-methyl-3-phenylpropionyl]-2-t-butyl-2,3-dihydro-1-methoxycarbonyl-4(1H)pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 0.5 h / -70 °C

2.1: Ti(O-i-Pr)4; TiCl₄; N,N-diisopropylethylamine / CH₂Cl₂

2.2: 79 percent / CH₂Cl₂ / 1 h / -78 °C

With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1246/bcsj.73.2423