siomycin A

Base Information

• Chemical Name: siomycin A
• CAS No.: 12656-09-6
• Molecular Formula: C71H81 N19 O18 S5
• Molecular Weight: 1648.84
• Mol file: 12656-09-6.mol

Synonyms:Alaninamide,L-threonyl-(4S)-2-[(1Z)-1-amino-1-propenyl]-4,5-dihydro-4-thiazolecarbonyl-2-[(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl]-4-thiazolecarbonyl-2-[(5R,6S)-6-[2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-thiazolyl]-5-[[N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl]amino]-5-(4-carboxy-2-thiazolyl)-3,4,5,6-tetrahydro-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-,(1'®4)-lactone, (4®1)-lactam (9CI); Siomycin A;17H,26H-4a,28-(Iminoethaniminoethaniminoethaniminoethanimino[7,2]quinolinomethanoxymethano)-8,5:18,15:25,22:32,29-tetranitrilo-4H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontine,cyclic peptide deriv.; NSC 285116

Chemical Property of siomycin A

Chemical Property:

• PKA: 10.43±0.46(Predicted)
• PSA: 701.00000
• Density: 1.65±0.1 g/cm3(Predicted)
• LogP: 3.82150
• Storage Temp.: ?20°C
• Solubility.: DMSO: complete10 mg/ml, clear, colorless to faintly yellow

Purity/Quality:

99% ^*data from raw suppliers

Siomycin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kill transformed but not normal cells. Siomycin A is an antibiotic that inhibits FoxM1.