Technology Process of 2,6-Piperidinedicarboxylic acid, 1-(phenylmethyl)-2-(2-propenyl)-,
dimethyl ester, (2R,6R)-
There total 6 articles about 2,6-Piperidinedicarboxylic acid, 1-(phenylmethyl)-2-(2-propenyl)-,
dimethyl ester, (2R,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Dimethyl cis-N-benzyl-2,6-piperidinedicarboxylate;
With
chiral bis-lithium amide base;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
allyl bromide;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1055/s-1999-2813
- Guidance literature:
-
Dimethyl cis-N-benzyl-2,6-piperidinedicarboxylate;
With
(R,R,R,R)-[PhCH(Me)N(Li)CHPh]2;
In
tetrahydrofuran;
at -78 ℃;
allyl bromide;
In
tetrahydrofuran;
Title compound not separated from byproducts;
DOI:10.1055/s-2004-831335
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 91 percent / H2 / Pd/C / ethanol / 10343 Torr
2.1: 86 percent / Na2CO3; H2O / CH2Cl2
3.1: chiral bis-lithium amide base / tetrahydrofuran / 1 h / -78 °C
3.2: 61 percent / tetrahydrofuran / -78 - 20 °C
With
chiral bis-lithium amide base; water; hydrogen; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Catalytic hydrogenation / 2.1: Alkylation / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1055/s-1999-2813
