Hydrazine hydrate

Base Information

• Chemical Name: Hydrazine hydrate
• CAS No.: 10217-52-4
• Deprecated CAS: 65209-65-6,65492-74-2,79785-97-0,65492-74-2,79785-97-0
• Molecular Formula: H4N2^.H2O
• Molecular Weight: 50.06
• Hs Code.: 28251010
• European Community (EC) Number: 600-285-7,616-584-0
• UN Number: 2030
• UNII: KYD297831P
• DSSTox Substance ID: DTXSID9037240
• Wikidata: Q3143689
• Mol file: 10217-52-4.mol

Synonyms:hydrazine;hydrazine dihydrochloride;hydrazine hydrate;hydrazine monohydrate;hydrazine mononitrate;hydrazine nitrate;hydrazine phosphate (1:1);hydrazine phosphate (2:1);hydrazine sulfate;hydrazine sulfate (1:1) monosodium salt;hydrazine sulfate (2:1);hydrazine tartrate;segidrin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Hydrazine hydrate

Chemical Property:

• Appearance/Colour: colorless fuming liquid
• Vapor Pressure: 5 mm Hg ( 25 °C)
• Melting Point: -51.5 °C
• Refractive Index: n20/D 1.428(lit.)
• Boiling Point: 113.5 °C at 760 mmHg
• Flash Point: 204°F
• PSA: 61.27000
• Density: 1.032 g/cm³
• LogP: 0.15510
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility.: miscible
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 50.048012819
• Heavy Atom Count: 3
• Complexity: 0

Purity/Quality:

Safty Information:

• Pictogram(s): T,N
• Hazard Codes: T,N
• Statements: 45-20/21/22-34-43-51/53-50/53-23/24/25
• Safety Statements: 53-45-60-61-36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazines
• Canonical SMILES: NN.O
• Uses: Hydrazine hydrate may be used to prepare: 3-(2-Benzyloxy-6-hydroxyphenyl)-5-styrylpyrazoles by reacting with 5-benzyloxy-2-styrylchromones.3,5-Diphenyl-2-pyrazoline derivatives by reacting with 1,3-diphenyl-2-propen-1-one.3′-Aryl-1,2,3,4,4′,5′-hexahydrospiro[quinoxalin-2,5′-pyrazol]-3-ones by reacting with 3-arylacylidene-3,4-dihydroquinoxalin-2(1H)-ones.It may also be used in the catalytic reduction of nitroarenes to aromatic amines. Hydrazine hydrate solution has been used as a reducing agent for tellurium oxide during the preparation of tellurium nanowires.

Refernces

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

10.3762/BJOC.16.144

The research presents a convergent strategy for synthesizing nitrogen-containing heterocycles, specifically indole, indolone, and cinnoline derivatives, from common 1,4-diketone and primary amine substrates. The authors demonstrate that by varying the substrates, substituents, or heating mode, they can selectively produce these derivatives in moderate to excellent yields. The study involves the preparation of variously substituted 1,4-diketones through Nef and Wittig reactions. The synthesis of indole and indolone derivatives is explored under different conditions, with the reaction mechanism involving imine formation and subsequent 1,2- or 1,4-addition processes. The synthesis of cinnoline derivatives is optimized using hydrazine monohydrate and acetic acid in ethanol under reflux conditions. The developed protocols are mild, metal-free, and functional-group tolerant, making them suitable for medicinal chemistry applications.

THE SYNTHESIS OF THIENOTRIAZOLOTHIAZEPINES

10.3987/COM-90-5442

The study detail the first synthesis of thienotriazolothiazepines, a novel heteroazepine derivative with anti-PAF (platelet activating factor) activity. The researchers synthesized these compounds to explore their potential as potent and orally active PAF antagonists. The synthetic route involved several steps, including the formation of 2-aminothiophenes, protection and reduction of amino groups, Mitsunobu conditions to form sulfides, hydrolysis to carboxylic acids, cyclization to form thiazepine rings, and the construction of triazole rings using Lawesson's reagent and subsequent treatments with hydrazine monohydrate and trimethyl orthoacetate. The synthesized thienotriazolothiazepines were tested for their ability to inhibit rabbit platelet aggregation induced by PAF, and all compounds exhibited anti-PAF activity. The study concludes that the synthesized compounds are effective in inhibiting PAF-induced platelet aggregation, suggesting their potential as therapeutic agents for conditions related to platelet aggregation.