10-Oxa-5-thia-2,8-diazadodecanoic acid, 7-[(1,1-dimethylethoxy)carbonyl]-4,11,11-trimethyl-9-oxo-, phenylmethyl ester, (4R,7R)-

Base Information

Chemical Name:10-Oxa-5-thia-2,8-diazadodecanoic acid, 7-[(1,1-dimethylethoxy)carbonyl]-4,11,11-trimethyl-9-oxo-, phenylmethyl ester, (4R,7R)-
CAS No.:251325-31-2
Molecular Formula:C23H36N2O6S
Molecular Weight:468.615
Hs Code.:
Mol file:251325-31-2.mol

Synonyms:

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Chemical Property of 10-Oxa-5-thia-2,8-diazadodecanoic acid, 7-[(1,1-dimethylethoxy)carbonyl]-4,11,11-trimethyl-9-oxo-, phenylmethyl ester, (4R,7R)-

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Technology Process of 10-Oxa-5-thia-2,8-diazadodecanoic acid, 7-[(1,1-dimethylethoxy)carbonyl]-4,11,11-trimethyl-9-oxo-, phenylmethyl ester, (4R,7R)-

There total 4 articles about 10-Oxa-5-thia-2,8-diazadodecanoic acid, 7-[(1,1-dimethylethoxy)carbonyl]-4,11,11-trimethyl-9-oxo-, phenylmethyl ester, (4R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 251325-34-5
toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-1-methyl-ethyl ester

: 98330-15-5
tert-butyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-sulfanylpropanoate

: 251325-31-2
1,1-dimethylethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-S-[(1R)-1-methyl-2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]-L-cysteinate

Guidance literature:: tert-butyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-sulfanylpropanoate; With potassium tert-butylate; In tetrahydrofuran; tert-butyl methyl ether; at 10 - 22 ℃; for 0.25h; Inert atmosphere; Large scale reaction;

toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-1-methyl-ethyl ester; In tetrahydrofuran; tert-butyl methyl ether; at 22 ℃; for 12h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op900108b

Reference yield:

: 251325-34-5
toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-1-methyl-ethyl ester

: 98330-15-5
tert-butyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-sulfanylpropanoate

: 251325-31-2
1,1-dimethylethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-S-[(1R)-1-methyl-2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]-L-cysteinate

: 1174921-41-5
C₂₃H₃₆N₂O₆S

Guidance literature:: With caesium carbonate; In acetonitrile; at 10 ℃; for 16h;

Reference yield:

: 251325-34-5
toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-1-methyl-ethyl ester

: 98330-15-5
tert-butyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-sulfanylpropanoate

: 251325-31-2
1,1-dimethylethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-S-[(1R)-1-methyl-2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]-L-cysteinate

: C₂₃H₃₆N₂O₆S

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/op900108b