Silane, (1,1-dimethylethyl)[(1S,2R)-3-iodo-1-[(1R)-1-[(2S,4S,5S)-2-(4-methoxy phenyl)-5-methyl-1,3-dioxan-4-yl]ethyl]-2-methylpropoxy]dimethyl-

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Chemical Name:Silane, (1,1-dimethylethyl)[(1S,2R)-3-iodo-1-[(1R)-1-[(2S,4S,5S)-2-(4-methoxy phenyl)-5-methyl-1,3-dioxan-4-yl]ethyl]-2-methylpropoxy]dimethyl-
CAS No.:252342-50-0
Molecular Formula:C24H41IO4Si
Molecular Weight:548.577
Hs Code.:
Mol file:252342-50-0.mol

Synonyms:

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Chemical Property of Silane, (1,1-dimethylethyl)[(1S,2R)-3-iodo-1-[(1R)-1-[(2S,4S,5S)-2-(4-methoxy phenyl)-5-methyl-1,3-dioxan-4-yl]ethyl]-2-methylpropoxy]dimethyl-

Chemical Property:

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Technology Process of Silane, (1,1-dimethylethyl)[(1S,2R)-3-iodo-1-[(1R)-1-[(2S,4S,5S)-2-(4-methoxy phenyl)-5-methyl-1,3-dioxan-4-yl]ethyl]-2-methylpropoxy]dimethyl-

There total 7 articles about Silane, (1,1-dimethylethyl)[(1S,2R)-3-iodo-1-[(1R)-1-[(2S,4S,5S)-2-(4-methoxy phenyl)-5-methyl-1,3-dioxan-4-yl]ethyl]-2-methylpropoxy]dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid (2S,3R,4R)-3-(tert-butyl-dimethyl-silanyloxy)-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentyl ester

: 252342-50-0
tert-Butyl-((1S,2R)-3-iodo-1-{(R)-1-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-2-methyl-propoxy)-dimethyl-silane

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/ja0015287

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 252342-50-0
tert-Butyl-((1S,2R)-3-iodo-1-{(R)-1-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-2-methyl-propoxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: Lut_.

2: LiBH₄ / tetrahydrofuran; ethanol

3: I₂; Ph₃P; imidazole / benzene; diethyl ether

With 1H-imidazole; lithium borohydride; iodine; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; benzene;
DOI:10.1021/ol9910870

Reference yield:

: 132969-62-1
(2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone

: 252342-50-0
tert-Butyl-((1S,2R)-3-iodo-1-{(R)-1-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-2-methyl-propoxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: Me₃Al / -78 °C

2: DDQ; 4 Angstroem MS

3: LAH / tetrahydrofuran

4: Bu₂BOTf

5: Lut_.

6: LiBH₄ / tetrahydrofuran; ethanol

7: I₂; Ph₃P; imidazole / benzene; diethyl ether

With 1H-imidazole; lithium aluminium tetrahydride; lithium borohydride; 4 Angstroem MS; di-n-butylboryl trifluoromethanesulfonate; iodine; trimethylaluminum; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; ethanol; benzene;
DOI:10.1021/ol9910870