t-Boc-Aminoxy-PEG3-alcohol

Base Information

• Chemical Name: t-Boc-Aminoxy-PEG3-alcohol
• CAS No.: 252378-66-8
• Molecular Formula: C₁₁H₂₃NO₆
• Molecular Weight: 265.307
• Mol file: 252378-66-8.mol

Synonyms:

Chemical Property of t-Boc-Aminoxy-PEG3-alcohol

Chemical Property:

• PKA: 14.36±0.10(Predicted)
• PSA: 86.25000
• Density: 1.109±0.06 g/cm3(Predicted)
• LogP: 0.85910
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

t-Boc-Aminooxy-PEG3-alcohol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: t-Boc-Aminooxy-PEG3-alcohol is a PEG3 derivative containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free aminooxy for further reaction.

Technology Process of t-Boc-Aminoxy-PEG3-alcohol

There total 6 articles about t-Boc-Aminoxy-PEG3-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C27H41NO6Si (918132-12-4) → C11H23NO6 (252378-66-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1055/s-2006-950246

Reference yield: 72.0%

tert-Butyl N-hydroxycarbamate (36016-38-3) + 2-[2-(2-iodoethoxy)ethoxy]ethanol (62573-16-4) → C11H23NO6 (252378-66-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 70 ℃; for 24h;

DOI:10.1016/S0040-4039(99)02331-X

Reference yield:

C30H35NO6Si (918132-08-8) → C11H23NO6 (252378-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂NNH₂*H₂O / ethanol / 18 h / 20 °C

2: 76 percent / Et₃N / CH₂Cl₂ / 18 h / Heating

3: 94 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

With tetrabutyl ammonium fluoride; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-2006-950246

upstream raw materials:

tert-Butyl N-hydroxycarbamate

2-[2-(2-iodoethoxy)ethoxy]ethanol

C₂₇H₄₁NO₆Si

C₃₀H₃₅NO₆Si

Refernces

• 1、 Dicus, Christopher W.,Nantz, Michael H.. "Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality". . p. 2821 - 2823. Retrieved 2008/02/11.