1,2-Benzenediol, 4-hexyl-

Base Information

• Chemical Name: 1,2-Benzenediol, 4-hexyl-
• CAS No.: 2524-98-3
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol file: 2524-98-3.mol

Synonyms:3.4-Dihydroxy-1-hexyl-benzol;4-n-Hexylcatechol;4-hexyl-pyrocatechol;4-Hexyl-brenzcatechin;

Chemical Property of 1,2-Benzenediol, 4-hexyl-

Chemical Property:

• Melting Point: 93-94 °C
• Boiling Point: 240-250 °C(Press: 15 Torr)
• PKA: 10.05±0.20(Predicted)
• PSA: 40.46000
• Density: 1.049±0.06 g/cm3(Predicted)
• LogP: 3.22060

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Benzenediol, 4-hexyl-

There total 12 articles about 1,2-Benzenediol, 4-hexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-hexyl-1,2-dimethoxy-benzene (92369-19-2) → 4-n-hexyl-catechol (2524-98-3)

Guidance literature:

With trimethylsilyl iodide; In acetonitrile; at 20 ℃; for 60h;

DOI:10.1002/ejoc.200300174

Reference yield: 80.0%

1-(3,4-Dihydroxyphenyl)-n-hexanol (118198-71-3) → 4-n-hexyl-catechol (2524-98-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; Ambient temperature; five drops 12N HCl;

DOI:10.1248/cpb.39.1736

Reference yield: 70.0%

4-n-hexyl-methylenedioxybenzene (126236-09-7) → 4-n-hexyl-catechol (2524-98-3)

Guidance literature:

With boron tribromide; at -70 ℃; for 2h;

DOI:10.1002/(SICI)1099-0461(1998)12:5<253::AID-JBT1>3.0.CO;2-K

upstream raw materials:

4-hexyl-1,2-dimethoxy-benzene

1-(3,4-Dihydroxyphenyl)-n-hexanol

4-n-hexyl-methylenedioxybenzene

1-(3,4-dimethoxyphenyl)-1-hexanone

Refernces

• 1、 Xiao, Zhu-Ping,Ma, Tao-Wu,Fu, Wei-Chang,Peng, Xiao-Chun,Zhang, Ai-Hua,Zhu, Hai-Liang. "The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors". experimental part. p. 5064 - 5070. Retrieved 2010/12/24.
• 2、 Sidhu,Marcus,Parkinson,Omiecinski. "Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures.". . p. 253 - 262. Retrieved 2007/10/03.