2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

Base Information

Chemical Name:2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione
CAS No.:252950-25-7
Molecular Formula:C19H14Cl2N2O3
Molecular Weight:389.238
Hs Code.:
DSSTox Substance ID:DTXSID101136348
Mol file:252950-25-7.mol

Synonyms:SCHEMBL5091381;KXFAAOZZTPTLLD-UHFFFAOYSA-N;DTXSID101136348;2-[1-(2,4-Dichlorobenzoyl)-2-(dimethylamino)ethenyl]-1H-isoindole-1,3(2H)-dione;2-{2-(2,4-dichlorophenyl)-1 -[(dimethylamino)methylene]-2-oxoethyl}-isoindoline-1,3-dione;2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}-isoindoline-1,3-dione;2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline -1,3-dione;2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione;2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline-1,3-dione;252950-25-7

Suppliers and Price of 2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:388.0381477
Heavy Atom Count:26
Complexity:610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C=C(C(=O)C1=C(C=C(C=C1)Cl)Cl)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of 2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione

There total 4 articles about 2-{2-(2,4-Dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline 1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 65146-53-4
2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dione

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 252950-25-7
2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 6h;
DOI:10.1021/acs.jmedchem.7b00922

Reference yield:

: 65146-53-4
2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dione

: 252950-25-7
2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide dimethyl acetal;

Reference yield:

: 4252-78-2
2,2',4'-trichloroacetophenone

: 252950-25-7
2-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 25 °C

2: N,N-dimethyl-formamide / 6 h / 80 °C

With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00922