2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride

Base Information

Chemical Name:2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride
CAS No.:252975-60-3
Molecular Formula:C8H4BrF5O3S
Molecular Weight:355.08
Hs Code.:
DSSTox Substance ID:DTXSID30591613
Wikidata:Q82485417
Mol file:252975-60-3.mol

Synonyms:252975-60-3;2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride;2-(4-BROMOPHENOXY)-1,1,2,2-TETRAFLUOROETHANESULFONYL FLUORIDE;4-Bromophenoxytetrafluoroethanesulphonyl fluoride;SCHEMBL4584804;DTXSID30591613;SPXWBVPRFLQEGR-UHFFFAOYSA-N;AKOS037652364;2-(4-Bromophenoxy)-perfluoroethane-1-sulfonyl fluoride

Suppliers and Price of 2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:353.89847
Heavy Atom Count:18
Complexity:386

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1OC(C(F)(F)S(=O)(=O)F)(F)F)Br

Technology Process of 2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride

There total 4 articles about 2-(4-Bromophenoxy)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 252975-56-7
2-(4-bromophenoxy)-1,1,2,2-tetrafluoroethanesulfonyl chloride

: 252975-60-3
2-(4-Bromophenoxy)tetrafluoroethanesulfonyl fluoride

Guidance literature:: With potassium fluoride; In acetonitrile; at 20 ℃; for 96h;
DOI:10.1016/S0022-1139(00)00308-0

Reference yield:

: 106-41-2
4-bromo-phenol

: 252975-60-3
2-(4-Bromophenoxy)tetrafluoroethanesulfonyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOH / methanol

1.2: 92 percent / dimethylsulfoxide / 6 h / 60 °C

2.1: 97 percent / aq. Na₂S₂O₄; NaHCO₃ / dimethylformamide / 4 h / 65 - 75 °C

3.1: 97 percent / Cl₂; H₂O / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h

4.1: 90 percent / KF / acetonitrile / 96 h / 20 °C

With potassium fluoride; potassium hydroxide; sodium dithionite; water; chlorine; sodium hydrogencarbonate; In methanol; 1,1,2-Trichloro-1,2,2-trifluoroethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Metallation / 1.2: Etherification / 2.1: Substitution / 3.1: Substitution / 4.1: Substitution;
DOI:10.1016/S0022-1139(00)00308-0

Reference yield:

: 113939-45-0
1-bromo-4-(2-bromo-1,1,2,2-tetrafluoroethoxy)benzene

: 252975-60-3
2-(4-Bromophenoxy)tetrafluoroethanesulfonyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / aq. Na₂S₂O₄; NaHCO₃ / dimethylformamide / 4 h / 65 - 75 °C

2: 97 percent / Cl₂; H₂O / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h

3: 90 percent / KF / acetonitrile / 96 h / 20 °C

With potassium fluoride; sodium dithionite; water; chlorine; sodium hydrogencarbonate; In 1,1,2-Trichloro-1,2,2-trifluoroethane; N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Substitution / 3: Substitution;
DOI:10.1016/S0022-1139(00)00308-0