Benzenemethanol, 4-[[(1,1-dimethylethyl)methoxyphenylsilyl]oxy]-2,6-dimethyl-a-[3-(1-meth ylethyl)-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-

Base Information

• Chemical Name: Benzenemethanol, 4-[[(1,1-dimethylethyl)methoxyphenylsilyl]oxy]-2,6-dimethyl-a-[3-(1-meth ylethyl)-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-
• CAS No.: 253329-12-3
• Molecular Formula: C₃₈H₅₈O₄Si₂
• Molecular Weight: 635.047
• Mol file: 253329-12-3.mol

Synonyms:

Chemical Property of Benzenemethanol, 4-[[(1,1-dimethylethyl)methoxyphenylsilyl]oxy]-2,6-dimethyl-a-[3-(1-meth ylethyl)-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, 4-[[(1,1-dimethylethyl)methoxyphenylsilyl]oxy]-2,6-dimethyl-a-[3-(1-meth ylethyl)-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-

There total 6 articles about Benzenemethanol, 4-[[(1,1-dimethylethyl)methoxyphenylsilyl]oxy]-2,6-dimethyl-a-[3-(1-meth ylethyl)-4-[[tris(1-methylethyl)silyl]oxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene (253329-09-8) + 4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-benzaldehyde (253329-11-2) → [4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-phenyl]-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methanol (253329-12-3)

Guidance literature:

4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

With cerium(III) chloride; In tetrahydrofuran; at -78 ℃;

4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-benzaldehyde; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0960-894X(01)00521-2

Reference yield:

2-(1-methylethyl)phenol (88-69-7) → [4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-phenyl]-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methanol (253329-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 63 percent / Br₂ / CH₂Cl₂

2.1: 72 percent / imidazole / 1,2-dichloro-ethane

3.1: n-BuLi / tetrahydrofuran / -78 °C

3.2: CeCl₃ / tetrahydrofuran / -78 °C

3.3: tetrahydrofuran / -78 °C

With 1H-imidazole; n-butyllithium; bromine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(01)00521-2

Reference yield:

4-bromo-3,5-dimethylphenol (7463-51-6) → [4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-phenyl]-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methanol (253329-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / CH₂Cl₂

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: 71 percent / tetrahydrofuran / -78 °C

3.1: n-BuLi / tetrahydrofuran / -78 °C

3.2: CeCl₃ / tetrahydrofuran / -78 °C

3.3: tetrahydrofuran / -78 °C

With n-butyllithium; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(01)00521-2

upstream raw materials:

4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene

4-(tert-butyl-methoxy-phenyl-silanyloxy)-2,6-dimethyl-benzaldehyde

2-(1-methylethyl)phenol

4-bromo-3,5-dimethylphenol

Downstream raw materials:

{4-[11-(butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undecyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

{4-[(Z)-11-(Butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undec-4-enyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

{4-[11-(butyl-methyl-carbamoyl)-1-(4-hydroxy-3-isopropyl-phenyl)-undecyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

{4-[(2,4-dimethoxy-phenyl)-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-methyl]-3,5-dimethyl-phenoxy}-acetic acid ethyl ester

Refernces