7-Aminoindolin-2-one

Base Information

• Chemical Name: 7-Aminoindolin-2-one
• CAS No.: 25369-32-8
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• European Community (EC) Number: 871-138-4
• DSSTox Substance ID: DTXSID90423683
• Wikidata: Q72438355
• Mol file: 25369-32-8.mol

Synonyms:7-aminoindolin-2-one;25369-32-8;7-aminooxindole;7-amino-1,3-dihydroindol-2-one;2H-Indol-2-one, 7-amino-1,3-dihydro-;MFCD12924258;7-amino-oxindole;7-Amino-1,3-dihydro-indol-2-one;7-amino-2-oxo-2,3-dihydro-1H-indole;SCHEMBL1654363;DTXSID90423683;AKOS006338896;SB64036;7-amino-2,3-dihydro-1H-indol-2-one;BS-16784;SY248415;CS-0188260;D80850;EN300-2960322;Z1203579747

Chemical Property of 7-Aminoindolin-2-one

Chemical Property:

• PSA: 58.61000
• Density: 1.307
• LogP: 1.42970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

7-Aminoindolin-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C(=CC=C2)N)NC1=O

Technology Process of 7-Aminoindolin-2-one

There total 7 articles about 7-Aminoindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

7-nitroindoline-2-one (25369-31-7) → 7-aminoindolin-2-one (25369-32-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 4h;

DOI:10.1016/j.bmc.2010.05.021

Reference yield: 36.0%

N-(2-oxoindolin-7-yl)acetamide (1168721-31-0) → 7-aminoindolin-2-one (25369-32-8)

Guidance literature:

With acetyl chloride; In methanol; at 20 ℃; for 1h;

DOI:10.1039/d0md00074d

Reference yield:

8-nitroquinoline (607-35-2) → 7-aminoindolin-2-one (25369-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O₂; AcOH / 70 °C

2: H₂ / 10 percent Pd/C / methanol; dimethylformamide

With hydrogen; dihydrogen peroxide; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Oxidation / 2: Reduction;

DOI:10.1016/S0960-894X(00)00219-5

upstream raw materials:

7-nitroindoline-2-one

8-nitroquinoline

2,6-difluoro-1-nitrobenzene

N-(2-oxoindolin-7-yl)acetamide

Downstream raw materials:

1-(4-methoxyphenyl)-3-(2-oxo-2,3-dihydro-1H-indol-7-yl)urea

N-(2-oxoindolin-7-ylcarbamoyl)-4-methoxybenzamide

4-nitro-N-(2-oxo-2,3-dihydro-1H-indol-7-yl)-benzenesulfonamide