5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid

Base Information

Chemical Name:5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid
CAS No.:25391-97-3
Molecular Formula:C12H10N2O3S
Molecular Weight:262.289
Hs Code.:
DSSTox Substance ID:DTXSID10529015
Wikidata:Q82399096
Mol file:25391-97-3.mol

Synonyms:25391-97-3;5-(Benzoylamino)-3-methyl-4-isothiazolecarboxylic Acid;5-BENZAMIDO-3-METHYL-1,2-THIAZOLE-4-CARBOXYLIC ACID;5-Benzamido-3-methylisothiazole-4-carboxylic acid;5-benzoylamino-3-methyl-isothiazole-4-carboxylic acid;SCHEMBL8706277;DTXSID10529015;3-methyl-5-benzoylaminoisothiazole-4-carboxylic acid;5-benzamido-3-methyl-1, 2-thiazole-4-carboxylic acid

Suppliers and Price of 5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid

Chemical Property:

Melting Point:121-122 °C
Boiling Point:285.5±40.0 °C(Predicted)
PKA:-0.84±0.25(Predicted)
PSA：111.02000
Density:1.458±0.06 g/cm3(Predicted)
LogP:2.78600
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:262.04121336
Heavy Atom Count:18
Complexity:331

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NSC(=C1C(=O)O)NC(=O)C2=CC=CC=C2
Uses 5-(Benzoylamino)-3-methyl-4-Isothiazolecarboxylic Acid, is the new isothiazole derivative, that is shown to have high antiviral activity, ability to inhibit reproduction of influenza, vaccinia, and herpes viruses in tissue cultures.

Technology Process of 5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid

There total 3 articles about 5-Benzamido-3-methyl-1,2-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53002-61-2
2-(1-amino-ethylidene)-N-benzoyl-3-thio-malonamic acid ethyl ester

: 25391-97-3
5-benzoylamino-3-methyl-4-isothiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂ / CHCl₃

2: aq. NaOH / 72 h

With sodium hydroxide; bromine; In chloroform;