Base Information
- Chemical Name:4H-3,1-Benzoxazine
- CAS No.:253-93-0
- Molecular Formula:C8H7NO
- Molecular Weight:
- Hs Code.:
- Mol file:253-93-0.mol
Synonyms:
Synonyms:
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The research focuses on the development of an efficient one-pot synthesis method for 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepine derivatives, which are compounds of potential biological importance due to their structure being a homolog of the 4H-3,1-benzoxazine skeleton found in many biologically active compounds. The experiments involve the reaction of 2-(2-aminophenyl)ethanols with acid chlorides in the presence of excess Et3N in THF at room temperature to form N-acylated intermediates, which are then dehydrated with POCl3 to yield the desired benzoxazepine derivatives. The reactants include 2-(2-aminophenyl)ethanols, acid chlorides, Et3N, THF, and POCl3. The analyses used to characterize the products encompass techniques such as infrared (IR) spectroscopy, proton and carbon-13 nuclear magnetic resonance (1H-NMR and 13C-NMR), mass spectrometry (MS), and elemental analysis, which are detailed in the experimental part of the article.
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