5-chloro-3-phenyl-1H-indole-2-carbohydrazide

Base Information

• Chemical Name: 5-chloro-3-phenyl-1H-indole-2-carbohydrazide
• CAS No.: 25434-84-8
• Molecular Formula: C15H12ClN3O
• Molecular Weight: 285.733
• DSSTox Substance ID: DTXSID60359182
• Wikidata: Q82140255
• ChEMBL ID: CHEMBL1432624
• Mol file: 25434-84-8.mol

Synonyms:5-chloro-3-phenyl-1H-indole-2-carbohydrazide;25434-84-8;MLS000769267;CHEMBL1432624;DTXSID60359182;HMS2793J15;STL336831;AKOS022133421;SMR000434001;5-chloro-3-phenyl -1h-indole-2-carbohydrazide;SR-01000394487;SR-01000394487-1;5-Chloro-3-phenyl-1H-indole-2-carboxylic acid hydrazide

Chemical Property of 5-chloro-3-phenyl-1H-indole-2-carbohydrazide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 285.0668897
• Heavy Atom Count: 20
• Complexity: 359

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(NC3=C2C=C(C=C3)Cl)C(=O)NN

Technology Process of 5-chloro-3-phenyl-1H-indole-2-carbohydrazide

There total 4 articles about 5-chloro-3-phenyl-1H-indole-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.7%

ethyl 3-phenyl-5-chloroindole-2-carboxylate (21139-32-2) → 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide (25434-84-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 - 80 ℃; for 6h;

DOI:10.1007/s00706-019-02457-9

Reference yield:

ethyl 2-[2-(4-chlorophenyl)hydrazinylidene]-3-phenylpropanoate (24139-99-9) → 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide (25434-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 4 h / 70 - 80 °C

2: hydrazine hydrate / ethanol / 6 h / 70 - 80 °C

With hydrogenchloride; hydrazine hydrate; In ethanol; water;

DOI:10.1007/s00706-019-02457-9

Reference yield:

Ethyl 2-benzylacetoacetate (620-79-1) → 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide (25434-84-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0 °C

1.2: 0 °C

2.1: hydrogenchloride / water / 4 h / 70 - 80 °C

3.1: hydrazine hydrate / ethanol / 6 h / 70 - 80 °C

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In ethanol; water;

DOI:10.1007/s00706-019-02457-9

upstream raw materials:

ethyl 3-phenyl-5-chloroindole-2-carboxylate

ethyl 2-[2-(4-chlorophenyl)hydrazinylidene]-3-phenylpropanoate

Ethyl 2-benzylacetoacetate

Downstream raw materials:

2-(5-Chloro-3-phenyl-1H-indole-2-carbonyl)-5-methyl-2,4-dihydro-pyrazol-3-one

1-phenyl-3-(5'-chloro-3'-phenyl-indole-2'-carboxamido)-thiourea

5-Chloro-3-phenyl-1H-indole-2-carboxylic acid [1-phenyl-eth-(E)-ylidene]-hydrazide

(5-Chloro-3-phenyl-1H-indol-2-yl)-(3,5-dimethyl-pyrazol-1-yl)-methanone