4-(methoxymethoxy)benzoic Acid

Base Information

• Chemical Name: 4-(methoxymethoxy)benzoic Acid
• CAS No.: 25458-44-0
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2918999090
• European Community (EC) Number: 891-277-4
• DSSTox Substance ID: DTXSID00460120
• Mol file: 25458-44-0.mol

Synonyms:4-(methoxymethoxy)benzoic Acid;25458-44-0;4-(MethoxyMethoxy)benzoicacid;MFCD21101751;Benzoic acid, 4-(methoxymethoxy)-;SCHEMBL155030;DTXSID00460120;XIFRBTZCMICRPL-UHFFFAOYSA-N;AKOS009075932;DS-11381;SY113685;4-(Methoxymethoxy)benzoic acid, AldrichCPR;CS-0150159;EN300-195568;Z149150724

Chemical Property of 4-(methoxymethoxy)benzoic Acid

Chemical Property:

• PSA: 55.76000
• LogP: 1.36750
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 161

Purity/Quality:

97% ^*data from raw suppliers

4-(Methoxymethoxy)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC=C(C=C1)C(=O)O

Technology Process of 4-(methoxymethoxy)benzoic Acid

There total 14 articles about 4-(methoxymethoxy)benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloromethyl methyl ether (107-30-2) + 4-hydroxy-benzoic acid (99-96-7) → 4-(methoxymethoxy)benzoic acid (25458-44-0)

Guidance literature:

chloromethyl methyl ether; 4-hydroxy-benzoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 17h;

With potassium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield: 97.0%

4-(methoxymethoxy)benzoic acid methoxymethyl ester → 4-(methoxymethoxy)benzoic acid (25458-44-0)

Guidance literature:

With water; potassium hydroxide; In methanol; at 20 ℃; for 5h;

Reference yield: 93.5%

ethyl 4-(methoxymethoxy)benzoate (5942-30-3) → 4-(methoxymethoxy)benzoic acid (25458-44-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 16h; Ambient temperature;

DOI:10.1016/S0957-4166(00)80176-7

upstream raw materials:

ethyl 4-(methoxymethoxy)benzoate

n-butyl 4-(methoxymethoxy)benzoate

4-hydroxy-benzoic acid

4-hydroxybenzoic acid, butyl ester

Downstream raw materials:

C₂₃H₂₀O₇

1-<4-(methoxymethoxy)phenyl>-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

N-(6-bromo-2-pyridyl)-4-(methoxymethoxy)benzamide

phenyl 4-(methoxymethoxy)benzoate