1-N-methyl-4-mercaptohistidine disulfide

Base Information

• Chemical Name: 1-N-methyl-4-mercaptohistidine disulfide
• CAS No.: 73491-33-5
• Molecular Formula: C₁₄H₂₀N₆O₄S₂
• Molecular Weight: 400.483
• Mol file: 73491-33-5.mol

Synonyms:L-OvothiolA disulfide

Chemical Property of 1-N-methyl-4-mercaptohistidine disulfide

Chemical Property:

• PSA: 212.88000
• LogP: 1.26240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-methyl-4-mercaptohistidine disulfide

There total 8 articles about 1-N-methyl-4-mercaptohistidine disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-ovothiol A (108418-13-9) → L-ovothiol A disulfide (73491-33-5)

Guidance literature:

With oxygen; copper dichloride; In water; at 5 ℃; for 12h; Yield given;

DOI:10.1021/jo00280a022

Reference yield:

5-(hydroxymethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methylimidazole (110117-69-6) → L-ovothiol A disulfide (73491-33-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / thionyl chloride / 0.5 h / 25 °C

2: tetrahydrofuran / -78 - 25 °C

3: 58 percent / aq. HCl / Heating

4: Hg(OCOCF₃)2, HOCOCF₃ / various solvent(s)

5: O₂, Cu²⁺

With hydrogenchloride; thionyl chloride; copper(II) ion; oxygen; mercury(II) trifluoroacetate; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/jo00228a060

Reference yield:

(S)-(4-methoxyphenyl)methyl-L-ovothiol A (110117-73-2) → L-ovothiol A disulfide (73491-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Hg(OCOCF₃)2, HOCOCF₃ / various solvent(s)

2: O₂, Cu²⁺

With copper(II) ion; oxygen; mercury(II) trifluoroacetate; trifluoroacetic acid; In various solvent(s);

DOI:10.1021/jo00228a060

upstream raw materials:

L-ovothiol A

5-(hydroxymethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methylimidazole

(S)-(4-methoxyphenyl)methyl-L-ovothiol A

5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride