2-Propanol, 1-(phenylseleno)-

Base Information

• Chemical Name: 2-Propanol, 1-(phenylseleno)-
• CAS No.: 25570-56-3
• Molecular Formula: C9H12OSe
• Molecular Weight: 215.154
• Mol file: 25570-56-3.mol

Synonyms:1-(phenylselanyl)propan-2-ol;2-hydroxypropyl phenyl selenide;1-Phenylselenopropan-2-ol;

Chemical Property of 2-Propanol, 1-(phenylseleno)-

Chemical Property:

• PSA: 20.23000
• LogP: 0.81520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propanol, 1-(phenylseleno)-

There total 14 articles about 2-Propanol, 1-(phenylseleno)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

phenyl trimethylsilyl selenide (33861-17-5) + methyloxirane (75-56-9,16033-71-9) → (RS)-1-(phenylseleno)-2-propanol (25570-56-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4h; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.104812

Reference yield: 93.0%

diphenyl diselenide (1666-13-3) + methyloxirane (75-56-9,16033-71-9) → (RS)-1-(phenylseleno)-2-propanol (25570-56-3)

Guidance literature:

With sodium dithionite; water; potassium carbonate; at 22 - 25 ℃; for 0.75h; regioselective reaction; Sonication;

DOI:10.3184/174751911X13149579868111

Reference yield: 91.0%

methyloxirane (75-56-9,16033-71-9) + phenylboronic acid (98-80-6) → (RS)-1-(phenylseleno)-2-propanol (25570-56-3)

Guidance literature:

phenylboronic acid; With selenium; silver nitrate; In dimethyl sulfoxide; at 120 ℃; for 2h;

methyloxirane; With potassium tert-butylate; In dimethyl sulfoxide; at 120 ℃; for 2h; stereoselective reaction;

DOI:10.1002/adsc.201800896

upstream raw materials:

Benzeneselenol

methyloxirane

2-(phenylselenyl)ethanol

phenyl tributylstannyl selenide

Downstream raw materials:

(S)-1-(phenylseleno)-2-propanol

1-(phenylselanyl)propan-2-one