(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol

Base Information

Chemical Name:(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol
CAS No.:256488-46-7
Molecular Formula:C12H9F3OS
Molecular Weight:258.264
Hs Code.:2934999090
DSSTox Substance ID:DTXSID60381802
Wikidata:Q82172871
Mol file:256488-46-7.mol

Synonyms:(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol;256488-46-7;[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methanol;2-(Hydroxymethyl)-4-phenyl-5-(trifluoromethyl)thiophene;SCHEMBL1029129;DTXSID60381802;MFCD01934530;CS-0450153;FT-0766983;4-Phenyl-5-trifluoromethylthiophene-2-methanol;[4-Phenyl-5-(trifluoromethyl)thien-2yl]methanol;2-Hydroxymethyl-4-phenyl-5-trifluoromethyl-thiophene;2-Hydroxymethyl-4phenyl-5-trifluoromethyl-thiophene

Suppliers and Price of (4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-(Hydroxymethyl)-4-phenyl-5-(trifluoromethyl)thiophene
1 g
$ 224.00

Crysdot
(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol 95+%
1g
$ 299.00

Chemenu
(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol 95%
1g
$ 282.00

Arctom
(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol
1g
$ 244.00

Apolloscientific
2-(Hydroxymethyl)-4-phenyl-5-(trifluoromethyl)thiophene
1g
$ 203.00

Alichem
(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol
1g
$ 400.00

Total 1 raw suppliers

Chemical Property of (4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol

Chemical Property:

Vapor Pressure:0.000382mmHg at 25°C
Boiling Point:304.5oC at 760 mmHg
PKA:13.49±0.10(Predicted)
Flash Point:138oC
PSA：48.47000
Density:1.348g/cm3
LogP:3.92620
Storage Temp.:2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:258.03262057
Heavy Atom Count:17
Complexity:251

Purity/Quality:: 2-(Hydroxymethyl)-4-phenyl-5-(trifluoromethyl)thiophene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(SC(=C2)CO)C(F)(F)F

Technology Process of (4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol

There total 4 articles about (4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 208108-76-3
(4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid

: 256488-46-7
2-hydroxymethyl-4-phenyl-5-trifluoromethylthiophene

Guidance literature:: With borane-THF; In tetrahydrofuran; for 3h; Heating;
DOI:10.1021/jm0492507

Reference yield:

: 350-92-5
1,1,1-Trifluoro-3-phenylpropan-2-one

: 256488-46-7
2-hydroxymethyl-4-phenyl-5-trifluoromethylthiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / phosphorus oxychloride / 20 h / 70 °C

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

3.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

4.1: 98 percent / BH₃*THF / tetrahydrofuran / 3 h / Heating

With sodium hydroxide; borane-THF; sodium hydride; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0492507

Reference yield:

: 119197-24-9,119197-25-0,146936-34-7
3-chloro-4,4,4-trifluoro-2-phenyl-but-2-enal

: 256488-46-7
2-hydroxymethyl-4-phenyl-5-trifluoromethylthiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 25 °C

1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

3.1: 98 percent / BH₃*THF / tetrahydrofuran / 3 h / Heating

With sodium hydroxide; borane-THF; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0492507