N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine

Base Information

Chemical Name:N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine
CAS No.:130031-44-6
Molecular Formula:C28H31 Cl2 N3
Molecular Weight:480.4718
Hs Code.:
DSSTox Substance ID:DTXSID50156309
Nikkaji Number:J351.878G
Wikidata:Q83024355
ChEMBL ID:CHEMBL1194825

Synonyms:N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine;130031-44-6;CHEMBL1194825;DTXSID50156309

Suppliers and Price of N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine

Chemical Property:

Vapor Pressure:4.3E-18mmHg at 25°C
Boiling Point:675.3°C at 760 mmHg
Flash Point:362.2°C
Density:1.229g/cm³
XLogP3:8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:12
Exact Mass:479.1895034
Heavy Atom Count:33
Complexity:511

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NCCCCCC4=CC=C(C=C4)N(CCCl)CCCl

Technology Process of N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine

There total 9 articles about N-(5-(4-(Bis(2-chloroethyl)amino)phenyl)pentyl)-9-acridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61346-09-6
6-(p-Nitrophenyl)-hexansaeuremethylester

: 130031-44-6
Acridin-9-yl-(5-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-pentyl)-amine

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Pd/C / ethyl acetate

2: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C

3: POCl₃ / benzene / 1 h / Heating

4: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min

5: EtOCOCl, Et₃N / acetone / 0.25 h / 0 °C

6: aq. NaN₃ / acetone / 0.5 h / 0 °C

7: benzene / 1 h / Heating

8: 8 N HCl / 0.17 h / Heating

9: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; chloroformic acid ethyl ester; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; acetone; benzene;
DOI:10.1021/jm00173a016

Reference yield:

: 123043-07-2
6-(4-Amino-phenyl)-hexanoic acid methyl ester

: 130031-44-6
Acridin-9-yl-(5-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-pentyl)-amine

Guidance literature:: Multi-step reaction with 8 steps

1: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C

2: POCl₃ / benzene / 1 h / Heating

3: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min

4: EtOCOCl, Et₃N / acetone / 0.25 h / 0 °C

5: aq. NaN₃ / acetone / 0.5 h / 0 °C

6: benzene / 1 h / Heating

7: 8 N HCl / 0.17 h / Heating

8: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; chloroformic acid ethyl ester; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jm00173a016

Reference yield:

: 130198-79-7
6-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-hexanoic acid

: 130031-44-6
Acridin-9-yl-(5-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-pentyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: EtOCOCl, Et₃N / acetone / 0.25 h / 0 °C

2: aq. NaN₃ / acetone / 0.5 h / 0 °C

3: benzene / 1 h / Heating

4: 8 N HCl / 0.17 h / Heating

5: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; chloroformic acid ethyl ester; triethylamine; In methanol; acetone; benzene;
DOI:10.1021/jm00173a016