2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate

Base Information

Chemical Name:2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate
CAS No.:259263-41-7
Molecular Formula:C14H18O4
Molecular Weight:250.295
Hs Code.:
Mol file:259263-41-7.mol

Synonyms:4-benzyloxytetrahydropyran-1-acetate;Acetic acid 5-benzyloxy-tetrahydro-pyran-2-yl ester;5-benzyloxytetrahydropyran-2-acetate;

Suppliers and Price of 2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate

Chemical Property:

PSA：44.76000
LogP:2.27140

Purity/Quality:: >=99.0% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate

There total 9 articles about 2H-Pyran-2-ol, tetrahydro-5-(phenylmethoxy)-, acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-benzyloxyoxytetrahydropyran-2-ol

: 108-24-7
acetic anhydride

: 259263-41-7
5-(benzyloxy)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 108-24-7
acetic anhydride

: 259263-40-6
5-benzyloxyoxytetrahydropyran-2-ol

: 259263-41-7
5-(benzyloxy)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: (R)-6-Methoxy-tetrahydro-pyran-3-ol

: 259263-41-7
5-(benzyloxy)tetrahydro-2H-pyran-2-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / tetrahydrofuran / 18 h / 80 °C

2: p-toluenesulfonic acid / H₂O; dioxane / 16 h / 70 °C

3: 4-dimethylaminopyridine / pyridine; CH₂Cl₂ / 12 h

With dmap; potassium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; 1: Aromatization / 2: Reduction / 3: Acetylation;
DOI:10.1021/ja993366o