5-BROMO-2-HYDROXYBENZYLAMINE

Base Information

• Chemical Name: 5-BROMO-2-HYDROXYBENZYLAMINE
• CAS No.: 58349-96-5
• Molecular Formula: C7H8 Br N O
• Molecular Weight: 202.051
• Hs Code.: 2922299090
• Mol file: 58349-96-5.mol

Synonyms:2-Hydroxy-5-bromobenzylamine;5-Bromo-2-hydroxybenzylamine; NSC 12210

Chemical Property of 5-BROMO-2-HYDROXYBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.000458mmHg at 25°C
• Boiling Point: 305.3°C at 760 mmHg
• Flash Point: 138.5°C
• PSA: 46.25000
• Density: 1.628g/cm³
• LogP: 2.31370
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-(AMINOMETHYL)-4-BROMOPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-HYDROXYBENZYLAMINE

There total 4 articles about 5-BROMO-2-HYDROXYBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

5-bromo-2-hydroxybenzamide (6329-74-4) → 2-Hydroxybenzylamine (932-30-9) + 2-hydroxy-5-bromobenzylamine (58349-96-5)

Guidance literature:

With sodium hydroxide; LiAlH₄; In tetrahydrofuran; water;

Reference yield:

5-bromo-2-hydroxybenzamide (6329-74-4) → 2-hydroxy-5-bromobenzylamine (58349-96-5)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; for 5.5h; Heating / reflux;

Reference yield:

5-bromo-2-hydroxybenzonitrile (40530-18-5) → 2-hydroxy-5-bromobenzylamine (58349-96-5)

Guidance literature:

5-bromo-2-hydroxybenzonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 18h; Reflux;

With hydrogenchloride; In methanol; for 0.5h; Reflux;

DOI:10.1021/acs.jmedchem.9b01573

upstream raw materials:

5-bromo-2-hydroxybenzamide

5-bromo-2-hydroxybenzonitrile

Downstream raw materials:

Fe₂(BrC₆H₃OCH₂NCHC₆H₄O)2(C₆H₅CO₂)2

Fe₂(BrC₆H₃OCH₂NCHC₆H₄O)2((C₆H₅O)2PO₂)2

6-bromo-3,4-dihydro-benzo[e][1,3]oxazin-2-one

benzyl (5-bromo-2-hydroxybenzyl)carbamate