4-Nonenoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4, 6,8-trimethyl-, 2,6-dimethylphenyl ester, (4Z,6S,7R,8S)-

Base Information

• Chemical Name: 4-Nonenoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4, 6,8-trimethyl-, 2,6-dimethylphenyl ester, (4Z,6S,7R,8S)-
• CAS No.: 261968-07-4
• Molecular Formula: C34H52O5Si
• Molecular Weight: 568.869
• Mol file: 261968-07-4.mol

Synonyms:

Chemical Property of 4-Nonenoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4, 6,8-trimethyl-, 2,6-dimethylphenyl ester, (4Z,6S,7R,8S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nonenoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4, 6,8-trimethyl-, 2,6-dimethylphenyl ester, (4Z,6S,7R,8S)-

There total 30 articles about 4-Nonenoic acid, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-4, 6,8-trimethyl-, 2,6-dimethylphenyl ester, (4Z,6S,7R,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

t-butyldimethylsiyl triflate (69739-34-0) + 2,6-dimethylphenyl (4Z,6S,7R,8S)-9-(p-methoxybenzyloxy)-7-hydroxy-4,6,8-trimethyl-4-nonenoate (373645-64-8) → (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 2,6-dimethylphenyl ester (261968-07-4)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1021/ja011211m

Reference yield: 86.0%

2.6-dimethylphenol (576-26-1,25134-01-4) + (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid (373645-85-3) → (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 2,6-dimethylphenyl ester (261968-07-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ja011211m

Reference yield: 80.0%

2.6-dimethylphenol (576-26-1,25134-01-4) + C32H58O5Si2 (827603-15-6) → (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 2,6-dimethylphenyl ester (261968-07-4)

Guidance literature:

C₃₂H₅₈O₅Si₂; With oxalyl dichloride; N,N-dimethyl-formamide;

2.6-dimethylphenol; With triethylamine;

DOI:10.1021/jo048534w

upstream raw materials:

2.6-dimethylphenol

(Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid

t-butyldimethylsiyl triflate

2,6-dimethylphenyl (4Z,6S,7R,8S)-9-(p-methoxybenzyloxy)-7-hydroxy-4,6,8-trimethyl-4-nonenoate

Downstream raw materials:

tert-Butyl-{(Z)-(1R,2S)-5-{(2R,3R)-2-[(Z)-(1R,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-oxetan-3-yl}-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane

(3Z,5S,6S,7R,8S,9R,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis(p-methoxybenzyloxy)-9-[(2,4,6-trimethylphenyl)sulfoxymethyl]-5,7,11,13,15-pentamethyl-hexadeca-1,3,11-trien-8-ol

1-[(5Z,13Z)-(2S,3R,4S,8S,9R,10R,11S,12S)-11-(4-methoxybenzoxy)-3,9-bis(tert-butyldimethylsilanyloxy)-2,4,6,8,10,12-hexamethylhexadeca-5,13,15-trienyloxymethyl]-4-methoxybenzene

(3Z,5S,6S,7S,8R,9R,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis(p-methoxybenzyloxy)-9-(hydroxymethyl)-5,7,11,13,15-pentamethylhexadeca-1,3,11-trien-8-ol