1-(1H-Indol-5-yl)cyclohexanol

Base Information

• Chemical Name: 1-(1H-Indol-5-yl)cyclohexanol
• CAS No.: 262593-62-4
• Molecular Formula: C14H17NO
• Molecular Weight: 215.295
• DSSTox Substance ID: DTXSID001307536
• Mol file: 262593-62-4.mol

Synonyms:1-(1H-Indol-5-yl)cyclohexanol;SCHEMBL7003023;YWVARHCIOPAINC-UHFFFAOYSA-N;DTXSID001307536;AKOS020022560;262593-62-4

Chemical Property of 1-(1H-Indol-5-yl)cyclohexanol

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 215.131014166
• Heavy Atom Count: 16
• Complexity: 247

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)(C2=CC3=C(C=C2)NC=C3)O

Technology Process of 1-(1H-Indol-5-yl)cyclohexanol

There total 1 articles about 1-(1H-Indol-5-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-1H-indole (10075-50-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 5-(1-hydroxylcyclohexyl)indole (262593-62-4)

Guidance literature:

5-bromo-1H-indole; With potassium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

cyclohexanone; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1021/ja0546830

Reference yield:

5-(1-hydroxylcyclohexyl)indole (262593-62-4) + 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 1-(3,5-di-O-p-toluoyl-2-deoxy-β-D-erythropentafuranosyl)-5-(1-hydroxyl)-cyclohexylindole

Guidance literature:

5-(1-hydroxylcyclohexyl)indole; With sodium hydride; In acetonitrile; at 20 ℃; for 1.5h;

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride; In acetonitrile; at 20 ℃; for 16h;

DOI:10.1021/ja0546830

Reference yield:

5-(1-hydroxylcyclohexyl)indole (262593-62-4) → 5-cyclohexyl-1H-indole (874948-87-5)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/ja0546830

upstream raw materials:

5-bromo-1H-indole

cyclohexanone

Downstream raw materials:

5-cyclohexyl-1H-indole

5-CHInd