3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one

Base Information

• Chemical Name: 3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one
• CAS No.: 26278-74-0
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol file: 26278-74-0.mol

Synonyms:1(2H)-Isoquinolinone,3,4-dihydro-3-phenyl;3,4-dihydro-3-phenylisoquinolin-1(2H)-one;3,4-Dihydro-3-phenylisocarbostyryl;3-phenyl-3,4-dihydro-1(2h)-isoquinolone;3,4-dihydro-3-phenyl-1(2H)-isoquinolinone;3-phenyl-3,4-dihydroisoquinolin-1(2H)-one;3-Phenyl-3,4-dihydro-2H-isochinolin-1-on;

Chemical Property of 3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property:

• PSA: 32.59000
• LogP: 2.72420

Purity/Quality:

99% ^*data from raw suppliers

3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one

There total 25 articles about 3-Phenyl-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-pivaloyl benzamide (89549-37-1) → 3,4-dihydro-3-phenyl-1(2H)-isoquinolinone (26278-74-0)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 20 ℃; for 24h; Darkness;

DOI:10.1002/chem.201804050

Reference yield: 90.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-(pivaloyloxy)benzamide (61650-22-4) → 3,4-dihydro-3-phenyl-1(2H)-isoquinolinone (26278-74-0)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/ja201143v

Reference yield: 83.0%

2-(2-Amino-2-phenyl-ethyl)-N,N-diethyl-benzamide → 3,4-dihydro-3-phenyl-1(2H)-isoquinolinone (26278-74-0)

Guidance literature:

With toluene-4-sulfonic acid; In xylene; for 48h;

DOI:10.1021/jo00233a013

upstream raw materials:

1-hydroxyisoquinoline

benzene

N,N-diethyl-ortho-toluamide

(E)-N-benzylidene-1,1,1-trimethylsilanamine

Downstream raw materials:

1-hydroxyisoquinoline

5,6,7,8-tetrahydro-1(2H)-isoquinolinone

3,4-dihydroisoquinolin-1(2H)-one