Benzenemethanol, a-(2-aminoethyl)-4-nitro-

Base Information

Chemical Name:Benzenemethanol, a-(2-aminoethyl)-4-nitro-
CAS No.:263392-93-4
Molecular Formula:C9H12N2O3
Molecular Weight:196.206
Hs Code.:

Synonyms:

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Chemical Property of Benzenemethanol, a-(2-aminoethyl)-4-nitro-

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Technology Process of Benzenemethanol, a-(2-aminoethyl)-4-nitro-

There total 7 articles about Benzenemethanol, a-(2-aminoethyl)-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 263392-92-3
3-methoxymethoxy-3-(4-nitrophenyl)-1-propylamine

: 263392-93-4
3-amino-1-(4-nitrophenyl)-propan-1-ol

Guidance literature:: 3-methoxymethoxy-3-(4-nitrophenyl)-1-propylamine; With bromocatecholborane; In dichloromethane; at -78 ℃; for 24h;

With acetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0040-4039(99)02200-5

Reference yield:

: 782496-82-6
1-methoxymethoxy-1-(4-nitrophenyl)-2-propene

: 263392-93-4
3-amino-1-(4-nitrophenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: B₂H₆ / tetrahydrofuran / 0 °C

1.2: 78 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

2.1: Et₃N; methanesulfonyl chloride / CH₂Cl₂ / 0.25 h / 0 °C

2.2: 91 percent / NaN₃; 15-crown-5 / dimethylformamide / 4.5 h / 20 °C

3.1: 72 percent / PPh₃; H₂O / tetrahydrofuran / 24 h / 20 °C

4.1: B-bromocatecholborane / CH₂Cl₂ / 2 h / -20 °C

4.2: 77 percent / acetic acid / CH₂Cl₂ / 7 h / 20 °C

With bromocatecholborane; water; methanesulfonyl chloride; triethylamine; triphenylphosphine; diborane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm051246n

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 263392-93-4
3-amino-1-(4-nitrophenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / tetrahydrofuran / 0.67 h / -50 °C

2.1: 95 percent / DIEA / CH₂Cl₂ / 24 h / 20 °C

3.1: B₂H₆ / tetrahydrofuran / 0 °C

3.2: 78 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

4.1: Et₃N; methanesulfonyl chloride / CH₂Cl₂ / 0.25 h / 0 °C

4.2: 91 percent / NaN₃; 15-crown-5 / dimethylformamide / 4.5 h / 20 °C

5.1: 72 percent / PPh₃; H₂O / tetrahydrofuran / 24 h / 20 °C

6.1: B-bromocatecholborane / CH₂Cl₂ / 2 h / -20 °C

6.2: 77 percent / acetic acid / CH₂Cl₂ / 7 h / 20 °C

With bromocatecholborane; water; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diborane; In tetrahydrofuran; dichloromethane; 1.1: Grignard reaction;
DOI:10.1021/jm051246n