4-(TERT-BUTYL)CYCLOHEXANONE OXIME

Base Information

• Chemical Name: 4-(TERT-BUTYL)CYCLOHEXANONE OXIME
• CAS No.: 4701-98-8
• Molecular Formula: C10H19NO
• Molecular Weight: 169.267
• Hs Code.: 2928000090
• Mol file: 4701-98-8.mol

Synonyms:Cyclohexanone,4-tert-butyl-, oxime (6CI,7CI,8CI);4-(1,1-Dimethylethyl)cyclohexanone oxime;4-tert-Butylcyclohexanone oxime;NSC 11346;

Chemical Property of 4-(TERT-BUTYL)CYCLOHEXANONE OXIME

Chemical Property:

• Vapor Pressure: 0.00448mmHg at 25°C
• Melting Point: 137-139 °C
• Refractive Index: 1.5
• Boiling Point: 257.2 °C at 760 mmHg
• Flash Point: 147.4 °C
• PSA: 32.59000
• Density: 0.99 g/cm³
• LogP: 3.05290

Purity/Quality:

99%min ^*data from raw suppliers

4-(tert-Butyl)cyclohexanoneOxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TERT-BUTYL)CYCLOHEXANONE OXIME

There total 5 articles about 4-(TERT-BUTYL)CYCLOHEXANONE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-tercbutyl-cyclohexanone (98-53-3) → 4-tert-butylcyclohexanone oxime (4701-98-8)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; at 20 ℃; for 0.666667h; grinding;

DOI:10.1007/s00706-005-0427-3

Reference yield:

spiro<(4-t-butyl cyclohexane)-1,2'-(4',4'-dimethyl oxazolidine-3' oxyl)> (34949-01-4) → 4-t-butyl cyclohexanoxime (4701-98-8) + spiro<(4-t-butyl cyclohexane)-1,2'-(4',4' oxazolidine 3'-hydroxy)> (75089-90-6) + 4-tercbutyl-cyclohexanone (98-53-3)

Guidance literature:

at 130 ℃; for 3h;

DOI:10.1016/S0040-4039(00)93654-2

Reference yield:

4-t-butyl-aci-nitrocyclohexane (53255-92-8) → trans-1-nitro-4-tert-butylcyclohexane (7214-34-8) + cis-4-t-butylnitrocyclohexane (7214-33-7) + 4-tert-butylcyclohexanone oxime (4701-98-8) + 4-tercbutyl-cyclohexanone (98-53-3)

Guidance literature:

In benzene; Mechanism; Ambient temperature; Irradiation; other α,β-unsaturated compounds;

upstream raw materials:

4-t-butyl-aci-nitrocyclohexane

4-tercbutyl-cyclohexanone

4-tert-butylcyclohexylamine

spiro<(4-t-butyl cyclohexane)-1,2'-(4',4'-dimethyl oxazolidine-3' oxyl)>

Downstream raw materials:

trans-4-t-butylcyclohexylamine

4-tert.-Butylcyclohexanimin

trans-1-nitro-4-tert-butylcyclohexane

cis-4-t-butylnitrocyclohexane

Refernces

• 1、 Grabowiecka, Agnieszka,Grela, Ewa,Macegoniuk, Katarzyna,Kozio?, Agata,Lochyński, Stanis?aw. "Synthesis of nitrogen-containing monoterpenoids with antibacterial activity". supporting information. p. 1074 - 1079. Retrieved 2019/01/29.
• 2、 Kürti, László,Kattamuri, Padmanabha V.,Siitonen, Juha H.,Yousufuddin, Muhammed. "Arylboronic Acid-Catalyzed C-Allylation of Unprotected Oximes: Total Synthesis of N-Me-Euphococcine". supporting information. . Retrieved 2020/03/24.