Base Information
- Chemical Name:3H-2,3-Benzodiazepine
- CAS No.:264-24-4
- Molecular Formula:C9H8N2
- Molecular Weight:144.176
- Hs Code.:
Synonyms:
Synonyms:
There total 1 articles about 3H-2,3-Benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 20.0%
Reference yield: 65.0%
1-(2,4,6-Trimethyl-phenyl)-3a,4-dihydro-3-oxa-2,10,10a-triaza-benzo[f]azulene
This research aims to develop straightforward synthetic methods for isoquino[2,3-c][2,3]benzoxazepinone and -[2,3]benzodiazepinones, as well as their precursors. The study builds on previous work involving the synthesis of azatetracycles and explores the potential of easily accessible compounds 4-6 for heterocyclic synthesis. The researchers used key chemicals such as isoquinolones (8a, 11a, and 17), dicarboxylic acids (4), and various reagents like ammonia, hydroxylamine, and hydrazine. They discovered that the isoquinolones can be cyclized to form the desired heterocyclic compounds through dehydration reactions. For instance, the reaction of dicarboxylic acid 4 with hydrazines (14a-c) yielded 2,3-benzodiazepines (15a, b, and 21). The study also observed that certain compounds, like oxime 10, rearrange thermally to form phthalide 12. The research concludes that these synthetic methods are effective and provide valuable pathways for the preparation of these heterocyclic compounds, which have potential pharmaceutical applications due to their diverse biological activities.
The study presents a new, environmentally friendly synthesis method for tofisopam, a 2,3-benzodiazepine type anxiolytic drug, which avoids the use of toxic chromium(VI) oxide reagents traditionally used in its production. The research focuses on replacing the hazardous chromium-based oxidation step with a lithiation-based approach to produce the key intermediate, a keto-ketal compound. The chemicals used in the study include (3,4-dimethoxyphenyl)acetone, bromine, lithium compounds (hexyllithium), 3,4-dimethoxybenzoyl chloride, and hydrazine, among others. These chemicals serve various purposes in the synthesis process, such as starting materials, reagents for protection and deprotection of functional groups, and agents for the lithiation and cyclization steps, ultimately leading to the formation of tofisopam without the environmental and health risks associated with chromium salts.
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