2-Furanpropanoic acid, b-oxo-a-(triphenylphosphoranylidene)-, ethyl ester

Base Information

• Chemical Name: 2-Furanpropanoic acid, b-oxo-a-(triphenylphosphoranylidene)-, ethyl ester
• CAS No.: 26480-96-6
• Molecular Formula: C27H23O4P
• Molecular Weight: 442.451
• Mol file: 26480-96-6.mol

Synonyms:

Chemical Property of 2-Furanpropanoic acid, b-oxo-a-(triphenylphosphoranylidene)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Furanpropanoic acid, b-oxo-a-(triphenylphosphoranylidene)-, ethyl ester

There total 5 articles about 2-Furanpropanoic acid, b-oxo-a-(triphenylphosphoranylidene)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-furancarbonyl chloride (527-69-5) → α-(2-furoyl)-α-(ethoxycarbonyl)methylenetriphenylphosphorane (26480-96-6)

Guidance literature:

With triethylamine; In dichloromethane; at 10 - 20 ℃; for 12.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.07.013

Reference yield: 82.0%

2-furancarbonyl chloride (527-69-5) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → α-(2-furoyl)-α-(ethoxycarbonyl)methylenetriphenylphosphorane (26480-96-6)

Guidance literature:

With triethylamine; In toluene; for 3h; Ambient temperature;

Reference yield:

triphenylphosphine (603-35-0) → α-(2-furoyl)-α-(ethoxycarbonyl)methylenetriphenylphosphorane (26480-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 72 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 10 - 15 °C

3: triethylamine / dichloromethane

With triethylamine; In dichloromethane;

DOI:10.1002/jhet.2186

upstream raw materials:

2-furancarbonyl chloride

ethyl (triphenylphosphoranylidene)acetate

triphenylphosphine

(ethoxycarbonylmethyl)triphenylphosphonium chloride

Downstream raw materials:

2-ethynylfuran

Refernces

• 1、 Komsani, Jayaram Reddy,Koppireddi, Satish,Avula, Sreenivas,Koochana, Pranay Kumar,Yadla, Rambabu. "Demonic axe-like conjugated alkynes in combating microbes". . p. 132 - 138. Retrieved 2013/10/01.