2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid

Base Information

Chemical Name:2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid
CAS No.:265129-71-3
Molecular Formula:C29H46N2O3S
Molecular Weight:502.75200
Hs Code.:
UNII:NTL2A9CAZ7
DSSTox Substance ID:DTXSID1040748
Nikkaji Number:J1.537.419E
Wikidata:Q27077952
Pharos Ligand ID:LALUWT63KL1L
Metabolomics Workbench ID:65252
ChEMBL ID:CHEMBL21241
Mol file:265129-71-3.mol

Synonyms:GW 7647;GW-7647;GW7647

Suppliers and Price of 2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GW7647
5mg
$ 185.00

Tocris
GW7647 ≥99%(HPLC)
50
$ 1135.00

Tocris
GW7647 ≥99%(HPLC)
10
$ 270.00

Sigma-Aldrich
GW7647 ≥98% (HPLC)
5mg
$ 203.00

Sigma-Aldrich
GW7647
5mg
$ 293.22

Sigma-Aldrich
GW7647 ≥98% (HPLC)
25mg
$ 798.00

DC Chemicals
GW7647 >98%
100 mg
$ 750.00

DC Chemicals
GW7647 >98%
250 mg
$ 1200.00

ChemScene
GW7647 98.22%
25mg
$ 312.00

ChemScene
GW7647 98.22%
10mg
$ 180.00

Total 23 raw suppliers

Chemical Property of 2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid

Chemical Property:

Vapor Pressure:3.26E-20mmHg at 25°C
Melting Point:156 - 157°C
Boiling Point:693.9oC at 760 mmHg
PKA:3.79±0.10(Predicted)
Flash Point:373.5oC
PSA：94.94000
Density:1.12
LogP:7.67020
Storage Temp.:Store at RT
Solubility.:DMSO: 16 mg/mL, soluble
XLogP3:8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:502.32291451
Heavy Atom Count:35
Complexity:636

Purity/Quality:

99%, ^*data from raw suppliers

GW7647 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)O)SC1=CC=C(C=C1)CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3
Description Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPARα It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 μM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.
Uses GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand: in defatting medium to treat primary human hepatocytes to test its effect on the glycolytic function in cardiomyocytes to test its effect on infant mouse heart in breast cancer MDA-MB-231 cells to activate PPARs GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. It can also be used for regenerative cardiac cell therapies.

Technology Process of 2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid

There total 1 articles about 2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%