[1]Benzopyrano[3,4-b]pyrrole-2-carboxylic acid, 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-7, 8-dimethoxy-4-oxo-

Base Information

• Chemical Name: [1]Benzopyrano[3,4-b]pyrrole-2-carboxylic acid, 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-7, 8-dimethoxy-4-oxo-
• CAS No.: 266674-77-5
• Molecular Formula: C32H31NO10
• Molecular Weight: 589.599
• Mol file: 266674-77-5.mol

Synonyms:

Chemical Property of [1]Benzopyrano[3,4-b]pyrrole-2-carboxylic acid, 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-7, 8-dimethoxy-4-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1]Benzopyrano[3,4-b]pyrrole-2-carboxylic acid, 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-7, 8-dimethoxy-4-oxo-

There total 28 articles about [1]Benzopyrano[3,4-b]pyrrole-2-carboxylic acid, 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-7, 8-dimethoxy-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-bis(3,4-dimethoxyphenyl)-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylic acid (917497-28-0) → 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylic acid (266674-77-5)

Guidance literature:

With lead(IV) acetate; In ethyl acetate; for 0.75h; Heating;

DOI:10.1055/s-2006-950191

Reference yield: 80.0%

methyl 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylate (266674-76-4) → 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylic acid (266674-77-5)

Guidance literature:

With lithium iodide; In N,N-dimethyl-formamide; for 84h; Heating;

DOI:10.1021/jo9916535

Reference yield:

dimethyl 3,4-dihydroxy-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate (570402-52-7) → 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylic acid (266674-77-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 87 percent / pyridine / 2 h / 0 °C

2.1: 78 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 4 h / Heating

3.1: 12 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

4.1: aq. KOH / 3 h / Heating

4.2: 76 percent / p-TsOH / toluene / 0.5 h / Heating

With potassium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; 2.1: Suzuki cross-coupling / 3.1: Suzuki cross-coupling;

DOI:10.1016/S0040-4039(03)01031-1

upstream raw materials:

methyl 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylate

3,4-bis(3,4-dimethoxyphenyl)-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylic acid

3,4-dimethoxyphenylpyruvic acid

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-7,8-dimethoxy-4-oxo-3H-[1]benzopyrano[3,4-b]pyrrole-4-one

14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one