5,7-Dichloro-2-methylquinoline

Base Information

• Chemical Name: 5,7-Dichloro-2-methylquinoline
• CAS No.: 26933-09-5
• Molecular Formula: C10H7Cl2N
• Molecular Weight: 212.07500
• Hs Code.: 2933499090
• European Community (EC) Number: 803-447-7
• DSSTox Substance ID: DTXSID20589084
• Wikidata: Q82482213
• Mol file: 26933-09-5.mol

Synonyms:5,7-Dichloro-2-methylquinoline;26933-09-5;SCHEMBL5258862;DTXSID20589084;BBA93309;MFCD09787758;AKOS022491961;AB52171;DK-0025;DB-067707;5,7-Dichloro-2-methylquinoline, AldrichCPR;CS-0316276;D80143

Chemical Property of 5,7-Dichloro-2-methylquinoline

Chemical Property:

• Vapor Pressure: 0.000984mmHg at 25°C
• Boiling Point: 312.2oC at 760 mmHg
• Flash Point: 171.7oC
• PSA: 12.89000
• Density: 1.351g/cm3
• LogP: 3.85000
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 210.9955546
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

98%min ^*data from raw suppliers

5,7-dichloro-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=C1)C(=CC(=C2)Cl)Cl

Technology Process of 5,7-Dichloro-2-methylquinoline

There total 3 articles about 5,7-Dichloro-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

acetaldehyde (75-07-0,9002-91-9) + 3,5-Dichloroaniline (626-43-7) → 2-methyl-5,7-dichloroquinoline (26933-09-5)

Guidance literature:

With hydrogenchloride; In water; at 0 - 75 ℃; for 4.25h;

Reference yield:

ethyl vinyl ether (109-92-2,25104-37-4) + 3,5-Dichloroaniline (626-43-7) → 2-methyl-5,7-dichloroquinoline (26933-09-5)

Guidance literature:

ethyl vinyl ether; 3,5-Dichloroaniline; With acetic acid; at 25 ℃; for 6h; Inert atmosphere;

for 5h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.1c03387

Reference yield:

3,5-Dichloroaniline (626-43-7) + crotonaldehyde (123-73-9,4170-30-3) → 2-methyl-5,7-dichloroquinoline (26933-09-5)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/j.bmcl.2006.11.031

upstream raw materials:

3,5-Dichloroaniline

crotonaldehyde

acetaldehyde

ethyl vinyl ether