2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide
CAS No.:269390-77-4
Molecular Formula:C₂₀H₁₆F₃N₃O
Molecular Weight:371.362
Hs Code.:
UNII:55K5464ZGS
ChEMBL ID:CHEMBL153843
Nikkaji Number:J3.170.363H
Pharos Ligand ID:HGQUHFBJ9B46
Wikidata:Q27456006
Mol file:269390-77-4.mol

Synonyms:2-((4-pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide;2-PMeA-3FMePhBzNH2

Suppliers and Price of 2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AAL-993
100mg
$ 1450.00

Sigma-Aldrich
VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 - CAS 269390-77-4 - Calbiochem
10mg
$ 164.00

Cayman Chemical
AAL-993 ≥95%
1mg
$ 64.00

Cayman Chemical
AAL-993 ≥95%
5mg
$ 113.00

ApexBio Technology
AAL-993
5mg
$ 143.00

ApexBio Technology
AAL-993
1mg
$ 82.00

American Custom Chemicals Corporation
AAL-993 95.00%
1MG
$ 177.45

American Custom Chemicals Corporation
AAL-993 95.00%
5MG
$ 502.63

AK Scientific
2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide
1mg
$ 179.00

Total 11 raw suppliers

Chemical Property of 2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide

Chemical Property:

Melting Point:158-160 °C
Boiling Point:441.3±45.0 °C(Predicted)
PKA:12.95±0.70(Predicted)
PSA：57.51000
Density:1.349±0.06 g/cm3(Predicted)
LogP:5.42180
Storage Temp.:+2C to +8C
Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:371.12454663
Heavy Atom Count:27
Complexity:480

Purity/Quality:

99%, ^*data from raw suppliers

AAL-993 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
Description AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50‘s 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
Uses AAL-993 is a VEGFR tyrosine kinase inhibitor that possess dual inhibition of VEGFR signaling and HIF-1α expression through ERK inhibition without affecting Akt phosphorylation.

Technology Process of 2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide

There total 1 articles about 2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: