N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide

Base Information

• Chemical Name: N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide
• CAS No.: 27030-98-4
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.288
• DSSTox Substance ID: DTXSID00357849
• Nikkaji Number: J1.079.283E
• Wikidata: Q82138019
• ChEMBL ID: CHEMBL341112
• Mol file: 27030-98-4.mol

Synonyms:N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide;27030-98-4;n-(4-(1h-benzo[d]imidazol-2-yl)phenyl)acetamide;Cambridge id 5751763;Oprea1_619141;CHEMBL341112;SCHEMBL2244714;DTXSID00357849;BZFARJUFSGWQCM-UHFFFAOYSA-N;2-(p-acetamidophenyl)benzimidazole;HMS1584L13;STK295778;AKOS001303198;AB00095780-01;EN300-1606392;N-[4-(1H-Benzoimidazol-2-yl)-phenyl]-acetamide;SR-01000219018;SR-01000219018-1;Z30270258;N-[4-(1H-1,3-BENZODIAZOL-2-YL)PHENYL]ACETAMIDE

Chemical Property of N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 251.105862047
• Heavy Atom Count: 19
• Complexity: 325

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)C2=NC3=CC=CC=C3N2

Technology Process of N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide

There total 12 articles about N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(1H-benzimidazol-2-yl)aniline (2963-77-1) + acetic anhydride (108-24-7) → N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)ethanamide (27030-98-4)

Guidance literature:

In benzene; for 4h; Heating;

DOI:10.1021/jm981076x

Reference yield: 89.0%

para-acetamidobenzaldehyde (122-85-0) + 1,2-diamino-benzene (95-54-5) → N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)ethanamide (27030-98-4)

Guidance literature:

With D-glucose; In water; at 60 ℃; for 7h; chemoselective reaction;

DOI:10.1080/00397911.2010.492460

Reference yield: 88.0%

benzoimidazole (51-17-2,79351-71-6) + 4-bromoacetanilide (103-88-8) → N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)ethanamide (27030-98-4)

Guidance literature:

With diisopropylisobutylamine; [RhCl(coe)2]2; In tetrahydrofuran; at 200 ℃; for 2h; microwave irradiation;

DOI:10.1021/ja0748985

upstream raw materials:

4-(1H-benzimidazol-2-yl)aniline

acetic anhydride

4-amino-benzoic acid

1,2-diamino-benzene

Downstream raw materials:

2-(4'-Acetamido-3'-nitrophenyl)-5-nitrobenzimidazole

2-(4'-Amino-3'-nitrophenyl)-5-nitrobenzimidazole