3-Phenyl-5,6,7,8-tetrahydrocinnoline

Base Information

• Chemical Name: 3-Phenyl-5,6,7,8-tetrahydrocinnoline
• CAS No.: 27219-25-6
• Molecular Formula: C14H14N2
• Molecular Weight: 210.279
• Mol file: 27219-25-6.mol

Synonyms:3-Phenyl-5,6,7,8-tetrahydro-cinnolin;3-Phenyl-5,6,7,8-tetrahydro-cinnoline;Cinnoline, 5,6,7,8-tetrahydro-3-phenyl-;5,6,7,8-Tetrahydro-3-phenyl-cinnolin;3-Phenyl-5,6,7,8-tetrahydro-cyclohexapyridazin;

Chemical Property of 3-Phenyl-5,6,7,8-tetrahydrocinnoline

Chemical Property:

• PSA: 25.78000
• LogP: 3.02240

Purity/Quality:

≥99% ^*data from raw suppliers

3-Phenyl-5,6,7,8-tetrahydrocinnoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-5,6,7,8-tetrahydrocinnoline

There total 12 articles about 3-Phenyl-5,6,7,8-tetrahydrocinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 4-chloro-4a,5,6,7,8,8a-hexahydro-8a-(4-morpholinyl)-3-phenyl-1(4H)-cinnolinecarboxylate → 5,6,7,8-tetrahydro-3-phenylcinnoline (27219-25-6)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; Heating;

DOI:10.1016/0040-4039(95)01128-5

Reference yield: 81.0%

2-(2-oxo-2-phenylethyl)cyclohex-2-en-1-one (33553-22-9) → 5,6,7,8-tetrahydro-3-phenylcinnoline (27219-25-6)

Guidance literature:

With acetic acid; hydrazine; In ethanol; water; for 16h; Reflux;

DOI:10.3762/BJOC.16.144

Reference yield: 23.0%

4-cyclohexen-1-ylmorpholine (670-80-4) + N'-[2,2-Dibromo-1-phenyl-eth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester (184103-47-7) → 5,6,7,8-tetrahydro-3-phenylcinnoline (27219-25-6) + (4R,4aS,8aR)-4-Bromo-8a-morpholin-4-yl-3-phenyl-4a,5,6,7,8,8a-hexahydro-4H-cinnoline-1-carboxylic acid ethyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Heating;

DOI:10.1021/jo960029e

upstream raw materials:

2-phenacylcyclohexanone

4-cyclohexen-1-ylmorpholine

N'-[2,2-Dibromo-1-phenyl-eth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester

N-ethoxycarbonyl-N'-(1-phenyl-ethylidene)-hydrazine

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