3-Fluoroglutamate

Base Information

Chemical Name:3-Fluoroglutamate
CAS No.:97315-76-9
Molecular Formula:C₅H₈FNO₄
Molecular Weight:165.121
Hs Code.:2922499990
DSSTox Substance ID:DTXSID80242865
Wikidata:Q83126731
Mol file:97315-76-9.mol

Synonyms:3-fluoroglutamate;3-fluoroglutamate, threo-isomer;3-fluoroglutamic acid

Suppliers and Price of 3-Fluoroglutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Fluoroglutamate

Chemical Property:

Vapor Pressure:1.72E-06mmHg at 25°C
Boiling Point:370°Cat760mmHg
Flash Point:177.6°C
PSA：100.62000
Density:1.498g/cm³
LogP:-0.08860
XLogP3:-3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:165.04373590
Heavy Atom Count:11
Complexity:172

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C(C(C(=O)O)N)F)C(=O)O
Isomeric SMILES:C([C@@H]([C@@H](C(=O)O)N)F)C(=O)O

Technology Process of 3-Fluoroglutamate

There total 4 articles about 3-Fluoroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 19883-18-2,97413-77-9,97413-78-0
D,L-erythro-N-acetyl-3-fluoroglutamic acid

: 97315-76-9,142292-79-3,97550-60-2,97550-65-7
(2R,3S)-3-fluoroglutamic acid

: 97550-59-9,142292-79-3,97550-60-2,97550-65-7
D-erythro-3-fluoroglutamic acid

Guidance literature:: In water; at 25 ℃; for 26h; acylase I, pH = 7;
DOI:10.1021/jo00217a029

Reference yield:

: 97315-80-5,97315-81-6
N-acetyl-3-hydroxyglutamic acid

: 97315-76-9,142292-79-3,97550-60-2,97550-65-7
(2R,3S)-3-fluoroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.540 g / hydrogen fluoride, sulfur tetrafluoride / 1 h / -78 °C

2: 40 percent / H₂O / 26 h / 25 °C / acylase I, pH = 7

With sulfur tetrafluoride; hydrogen fluoride; In water;
DOI:10.1021/jo00217a029

Reference yield:

: 1608-58-8
diethyl 2-oxo-3-carbetoxy-3-fluoroglutarate

: 97315-76-9,142292-79-3,97550-60-2,97550-65-7
(2R,3S)-3-fluoroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CH₃COOH, HCl / 1.) RT, 3 d, 2.) 50 deg C, 5 h

2: ethanol / 72 h / 30 °C / EDTA, NAD⁽¹⁺⁾, bovine serum albumin, GLDH, YADH, ammonium phosphate buffer (pH 7)

With hydrogenchloride; acetic acid; In ethanol;
DOI:10.1021/jo00263a048