2-Benzofurancarboxylic acid, 3-methyl-4-[3-[(phenylmethyl)amino]propoxy]-, ethyl ester

Base Information

• Chemical Name: 2-Benzofurancarboxylic acid, 3-methyl-4-[3-[(phenylmethyl)amino]propoxy]-, ethyl ester
• CAS No.: 279230-22-7
• Molecular Formula: C22H25NO4
• Molecular Weight: 367.43800
• Mol file: 279230-22-7.mol

Synonyms:4-(3-Benzylamino-propoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester;

Chemical Property of 2-Benzofurancarboxylic acid, 3-methyl-4-[3-[(phenylmethyl)amino]propoxy]-, ethyl ester

Chemical Property:

• Boiling Point: 511.7±50.0 °C(Predicted)
• PSA: 60.70000
• Density: 1.148±0.06 g/cm3(Predicted)
• LogP: 4.86750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzofurancarboxylic acid, 3-methyl-4-[3-[(phenylmethyl)amino]propoxy]-, ethyl ester

There total 7 articles about 2-Benzofurancarboxylic acid, 3-methyl-4-[3-[(phenylmethyl)amino]propoxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzylamine (100-46-9) + 4-(3-bromopropoxy)-3-methylbenzofuran-2-carboxylic acid ethyl ester (279230-75-0) → 4-(3-benzylamino-propoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester (279230-22-7)

Guidance literature:

In ethanol; at 60 ℃; for 9h;

DOI:10.1016/S0968-0896(03)00429-2

Reference yield:

4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (3781-69-9) → 4-(3-benzylamino-propoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester (279230-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / potassium carbonate / dimethylformamide / 4 h / 20 °C

2: 85 percent / ethanol / 9 h / 60 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00429-2

Reference yield:

2,6-dihydroxylacetophenone (699-83-2) → 4-(3-benzylamino-propoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester (279230-22-7)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / acetone / 15 h / 60 °C

2: NaOEt / ethanol / 20 h / 0 °C

3: K₂CO₃ / dimethylformamide / 20 °C

4: ethanol / 70 °C

With sodium ethanolate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0960-894X(01)00319-5

upstream raw materials:

benzylamine

4-(3-bromopropoxy)-3-methylbenzofuran-2-carboxylic acid ethyl ester

4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

2,6-dihydroxylacetophenone