Pyrimidine, 4-methoxy-5-phenyl-

Base Information

• Chemical Name: Pyrimidine, 4-methoxy-5-phenyl-
• CAS No.: 27956-27-0
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Mol file: 27956-27-0.mol

Synonyms:

Chemical Property of Pyrimidine, 4-methoxy-5-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrimidine, 4-methoxy-5-phenyl-

There total 7 articles about Pyrimidine, 4-methoxy-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydroxy-4 p-nitrophenyl-5 pyrimidine (22433-73-4) → 4-methoxy-5-phenyl-pyrimidine (27956-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / CHCl₃; diethyl ether / 1.) 5 degC, 2.) RT, 3-5 d

2: 92 percent / ammonia, hydrogene sulfure

3: 1.) conc. hydrochloric acid, sodium nitrite 2.) 30 percent (H₃PO₂) / 1.) H₂O, 5 deg C, 2 h 2.) 5 deg C, 20 h, 25 deg C, 8 h

With hydrogenchloride; hydrogen sulfide; ammonia; hypophosphorous acid; sodium nitrite; In diethyl ether; chloroform;

Reference yield:

methoxy-4 p-aminophenyl-5 pyrimidine (77654-73-0) → 4-methoxy-5-phenyl-pyrimidine (27956-27-0)

Guidance literature:

With hydrogenchloride; hypophosphorous acid; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, 5 deg C, 2 h 2.) 5 deg C, 20 h, 25 deg C, 8 h;

Reference yield:

4-methoxy-5-(4-nitro-phenyl)-pyrimidine (27956-28-1) → 4-methoxy-5-phenyl-pyrimidine (27956-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / ammonia, hydrogene sulfure

2: 1.) conc. hydrochloric acid, sodium nitrite 2.) 30 percent (H₃PO₂) / 1.) H₂O, 5 deg C, 2 h 2.) 5 deg C, 20 h, 25 deg C, 8 h

With hydrogenchloride; hydrogen sulfide; ammonia; hypophosphorous acid; sodium nitrite;

upstream raw materials:

4-chloro-5-phenylpyrimidine

sodium methylate

methoxy-4 p-aminophenyl-5 pyrimidine

hydroxy-4 p-nitrophenyl-5 pyrimidine

Downstream raw materials:

3-methyl-5-phenyl-3H-pyrimidin-4-one

1-methyl-5-phenyl-1H-pyrimidin-4-one

4-Methoxy-5-phenyl-pyrimidine-2-carbonitrile

4-Methoxy-5-phenyl-pyrimidine 1-oxide