DL-Cyclobutylglycine

Base Information

• Chemical Name: DL-Cyclobutylglycine
• CAS No.: 28024-69-3
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID70559272
• Mol file: 28024-69-3.mol

Synonyms:2-Cyclobutylglycine;2-CYCLOBUTYL-DL-GLYCINE;

Chemical Property of DL-Cyclobutylglycine

Chemical Property:

• Melting Point: 157-161℃
• Boiling Point: 240℃ (DEC.)
• PKA: 2.49±0.10(Predicted)
• Flash Point: 112℃
• PSA: 63.32000
• Density: 1.231
• LogP: 0.89870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.078978594
• Heavy Atom Count: 9
• Complexity: 120

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-2-cyclobutylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C1)C(C(=O)O)N

Technology Process of DL-Cyclobutylglycine

There total 3 articles about DL-Cyclobutylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.9%

aminocyclobutylacetonitrile → 2-amino-2-cyclobutylacetic acid (28024-69-3)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 6h;

Reference yield:

cyclobutylaldehyde (2987-17-9) → 2-amino-2-cyclobutylacetic acid (28024-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium sulfate; ammonia / water; methanol / 10 h / 40 °C

2: water; hydrogenchloride / 6 h / 80 °C

With hydrogenchloride; ammonium sulfate; ammonia; water; In methanol; water;

Reference yield:

→ 2-amino-2-cyclobutylacetic acid (28024-69-3)

Guidance literature:

5-Cyclobutylhydantoin , H2O / LiOH;

upstream raw materials:

cyclobutylaldehyde

Downstream raw materials:

C₇H₁₃NO₂