2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid

Base Information

Chemical Name:2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid
CAS No.:28077-43-2
Molecular Formula:C11H8ClNO2S
Molecular Weight:253.709
Hs Code.:
DSSTox Substance ID:DTXSID50593775
Wikidata:Q82488321
Mol file:28077-43-2.mol

Synonyms:28077-43-2;2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid;SCHEMBL4458525;DTXSID50593775;YHSICJIHHKUPAU-UHFFFAOYSA-N;DB-423208;2-Chloro-5-(2-methyl-4-thiazolyl)benzoic acid;2-Chloro-5-(2-methyl-thiazol-4-yl)-benzoic acid

Suppliers and Price of 2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid

Chemical Property:

PSA：78.43000
LogP:3.47010
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:252.9964274
Heavy Atom Count:16
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CS1)C2=CC(=C(C=C2)Cl)C(=O)O

Technology Process of 2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid

There total 5 articles about 2-Chloro-5-(2-methyl-1,3-thiazol-4-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 792912-04-0
2-chloro-5-(2-methyl-thiazol-4-yl)-benzoic acid methyl ester

: 28077-43-2
2-chloro-5-(2-methyl thiazol-4-yl)-benzoic acid

Guidance literature:: With sodium hydroxide; water; In tert-butyl alcohol; at 20 ℃; for 72h;

Reference yield:

: 625470-33-9
methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 28077-43-2
2-chloro-5-(2-methyl thiazol-4-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

2: methanol; sodium hydroxide

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; sodium hydroxide; In 1,4-dioxane; 1: Suzuki reaction;
DOI:10.1016/j.bmcl.2011.06.117

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 28077-43-2
2-chloro-5-(2-methyl thiazol-4-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / water

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / Heating

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 80 °C / Molecular sieve

4: methanol; sodium hydroxide

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: Suzuki reaction;
DOI:10.1016/j.bmcl.2011.06.117