INDOMETHACIN ESTER, N-HEPTYL-

Base Information

Chemical Name:INDOMETHACIN ESTER, N-HEPTYL-
CAS No.:282728-47-6
Molecular Formula:C26H30ClNO4
Molecular Weight:455.97400
Hs Code.:
Mol file:282728-47-6.mol

Synonyms:

Suppliers and Price of INDOMETHACIN ESTER, N-HEPTYL-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Indomethacin heptyl ester ≥98%
5mg
$ 86.00

Cayman Chemical
Indomethacin heptyl ester ≥98%
1mg
$ 19.00

Cayman Chemical
Indomethacin heptyl ester ≥98%
10mg
$ 152.00

Cayman Chemical
Indomethacin heptyl ester ≥98%
50mg
$ 665.00

ApexBio Technology
Indomethacinheptylester
10mg (solution)
$ 210.00

AK Scientific
Indomethacinheptylester
1mg
$ 125.00

Total 17 raw suppliers

Chemical Property of INDOMETHACIN ESTER, N-HEPTYL-

Chemical Property:

Flash Point:-16?°C
PSA：57.53000
LogP:6.35630
Storage Temp.:−20°C
Solubility.:≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

Indomethacin heptyl ester ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F,Xi
Statements: 11-36-66-67
Safety Statements: 16-26-29-33-36

MSDS Files:: SDS file from LookChem

Useful:

Description Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC50 of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 μM.

Technology Process of INDOMETHACIN ESTER, N-HEPTYL-

There total 1 articles about INDOMETHACIN ESTER, N-HEPTYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%