INDOMETHACIN N-OCTYL AMIDE

Base Information

• Chemical Name: INDOMETHACIN N-OCTYL AMIDE
• CAS No.: 282728-65-8
• Molecular Formula: C27H33ClN2O3
• Molecular Weight: 469.01600
• Mol file: 282728-65-8.mol

Synonyms:

Chemical Property of INDOMETHACIN N-OCTYL AMIDE

Chemical Property:

• PSA: 63.82000
• LogP: 7.15970
• Solubility.: ≤2mg/ml in ethanol;27mg/ml in dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

Indomethacin N-octyl amide ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of INDOMETHACIN N-OCTYL AMIDE

There total 1 articles about INDOMETHACIN N-OCTYL AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

n-Octylamine (111-86-4) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → N-octyl-(1-p-chlorobenzoyl-5-methoxy-2-methylindole)-3-acetamide (282728-65-8)

Guidance literature:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

n-Octylamine; In dichloromethane; at 20 ℃; Further stages.;

DOI:10.1021/jm000004e

upstream raw materials:

n-Octylamine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Refernces