L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

Base Information

Chemical Name:L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)
CAS No.:285139-32-4
Molecular Formula:C27H33N5O6S
Molecular Weight:555.655
Hs Code.:
Mol file:285139-32-4.mol

Synonyms:

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Chemical Property of L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

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Technology Process of L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

There total 3 articles about L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 285139-36-8
N-(5-aminopyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 285139-32-4
N-[5-(N-4-toluenesulfonyl-amino)pyrimidin-4-yl]-L-4-(N,N-dimethylcarbarnyloxy)phenylalanine tert-butyl ester

Guidance literature:: N-(5-aminopyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester; p-toluenesulfonyl chloride; With pyridine; at 0 ℃; for 3h;

With 1-amino-3-(dimethylamino)propane; In pyridine; at 20 ℃; for 0.5h;

Reference yield:

: 285139-31-3
N-(2-chloro-5-nitropyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

: 285139-32-4
N-[5-(N-4-toluenesulfonyl-amino)pyrimidin-4-yl]-L-4-(N,N-dimethylcarbarnyloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen; sodium hydrogencarbonate / ethanol

2: pyridine

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In pyridine; ethanol;
DOI:10.1016/j.bmcl.2013.03.010

Reference yield:

: 284486-57-3
L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

: 285139-32-4
N-[5-(N-4-toluenesulfonyl-amino)pyrimidin-4-yl]-L-4-(N,N-dimethylcarbarnyloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethyl-N-isopropylamine / dichloromethane / 0 °C

2: palladium on activated charcoal; hydrogen; sodium hydrogencarbonate / ethanol

3: pyridine

With N,N-diethyl-N-isopropylamine; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In pyridine; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.010