Benzeneacetic acid, .alpha.-broMo-2-chloro-, ethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, .alpha.-broMo-2-chloro-, ethyl ester
• CAS No.: 2856-79-3
• Molecular Formula: C10H10BrClO2
• Molecular Weight: 277.545
• Mol file: 2856-79-3.mol

Synonyms:2-bromo-2-(2-chlorophenyl)acetic acid ethyl ester;ethyl 2-bromo-(2'-chloro)phenylacetate;ethyl 2-bromo-2-(2-chloro-phenyl)acetate;ethyl 2-bromo-2-(2-chlorophenyl)acetate;ethyl α-bromoorthochlorophenylacetate;BENZENEACETIC ACID,.ALPHA.-BROMO-2-CHLORO-,ETHYL ESTER;α-Brom-2-chlor-phenylessigsaeure-ethylester;

Chemical Property of Benzeneacetic acid, .alpha.-broMo-2-chloro-, ethyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 3.33910

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-bromo-2-(2-chlorophenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, .alpha.-broMo-2-chloro-, ethyl ester

There total 7 articles about Benzeneacetic acid, .alpha.-broMo-2-chloro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chlorophenylacetic acid ethyl ester (40061-54-9) → ethyl α-bromo-2-chlorophenylacetate (2856-79-3)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 8h; Heating / reflux;

Reference yield: 83.0%

o-chlorophenyldiazoacetic acid ethyl ester (1398179-33-3) → ethyl α-bromo-2-chlorophenylacetate (2856-79-3)

Guidance literature:

With cobalt(II) bromide hexahydrate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.202000009

Reference yield:

ethyl 2-(2-chlorophenyl)-2-hydroxyacetate (13511-30-3,871836-58-7) → ethyl α-bromo-2-chlorophenylacetate (2856-79-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; Yield given;

DOI:10.1021/jm00075a033

upstream raw materials:

2-chlorophenylacetic acid ethyl ester

ethyl 2-(2-chlorophenyl)-2-hydroxyacetate

2'-chloro-benzeneacetic acid

2-chloro-α-[(trimethylsilyl)oxy]benzeneacetonitrile

Downstream raw materials:

ethyl (+/-)-2-(2-chlorophenyl)-2-(1H-imidazol-1-yl)acetate

2-(2-chloro-phenyl)-4H-benzo[1,4]thiazin-3-one

3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine