diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester

Base Information

• Chemical Name: diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester
• CAS No.: 245759-70-0
• Molecular Formula: C₃₃H₄₀N₆O₅
• Molecular Weight: 600.718

Synonyms:

Chemical Property of diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester

Chemical Property:

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Technology Process of diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester

There total 3 articles about diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,5R)-5-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (104291-16-9) → diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester (245759-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / sodium nitrite; acetic acid

With acetic acid; sodium nitrite; 1: Deamination / 2: Acylation / 3: Substitution;

DOI:10.1080/07328319908044781

Reference yield:

4-amino-7-(2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-2(3H)-one (103173-80-4) → diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester (245759-70-0)

Guidance literature:

1: Acylation / 2: Substitution;

DOI:10.1080/07328319908044781

Reference yield:

N,N-dibutylformamide dimethyl acetal (19449-30-0) + 4-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl diphenylcarbamate (198008-12-7) → diphenyl-carbamic acid 4-(dibutylamino-methyleneamino)-7-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl ester (245759-70-0)

Guidance literature:

DOI:10.1080/07328319908044781

upstream raw materials:

N,N-dibutylformamide dimethyl acetal

4-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl diphenylcarbamate

(2R,3S,5R)-5-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

4-amino-7-(2-deoxy-β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-2(3H)-one

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